IL12B Antibody (PACO27589)
- SKU:
- PACO27589
- Product Type:
- Antibody
- Reactivity:
- Sheep
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | IL12B Antibody (PACO27589) |
| Antibody SKU: | PACO27589 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| Species Reactivity: | Sheep |
| Immunogen: | Recombinant Sheep Interleukin-12 subunit β protein (23-327AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Interleukin-12 subunit beta antibody at 14µg/ml + K562 whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 37 kDa Observed band size: 37 kDa . |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO27589 at dilution of 1:10. |
 | Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO27589 at dilution of 1:10. |
| Background: | Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-γ by resting PBMC By similarity.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis By similarity. |
| Synonyms: | Interleukin-12 subunit β (IL-12B) (Cytotoxic lymphocyte maturation factor 40 kDa subunit) (CLMF p40) (IL-12 subunit p40), IL12B |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P68220 |
| NCBI GenInfo Identifier: | 57164231 |
| NCBI Gene ID: | 443472 |
| NCBI Accession: | NP_001009438.1 |
| UniProt Secondary Accession: | P68220 |
| UniProt Related Accession: | P68220 |
| Molecular Weight: | |
| NCBI Full Name: | interleukin-12 subunit beta |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | IL12B |
| NCBI Official Synonym Symbols: | IL-12 |
| NCBI Protein Information: | interleukin-12 subunit beta |
| UniProt Protein Name: | |
| UniProt Synonym Protein Names: | |
| Protein Family: | |
| UniProt Gene Name: | |
| UniProt Entry Name: |
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