IL1β Monoclonal Antibody (CAB24243)
- SKU:
- CAB24243
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
Description
| Product Name: | IL1β Monoclonal Antibody |
| Product Code: | CAB24243 |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53391 |
| Reactivity: | Human |
| Tested Applications: | FC, FC(Intra), ELISA |
| Recommended Dilution: | FC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.03% proclin300, 0.2% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted, autophagosome, cytosol, exosome |
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 117-269 of human IL1β (NP_000567.1). |
| Sequence: | APVRS LNCTL RDSQQ KSLVM SGPYE LKALH LQGQD MEQQV VFSMS FVQGE ESNDK IPVAL GLKEK NLYLS CVLKD DKPTL QLESV DPKNY PKKKM EKRFV FNKIE INNKL EFESA QFPNW YISTS QAENM PVFLG GTKGG QDITD FTMQF VSS |
| Synonyms: | IL1B, IL-1, IL1-BETA, IL1F2, interleukin-1 beta |
| Calculated MW: | 30kDa |
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