Growth Factors & Cytokines Recombinant Proteins
IL-22 Recombinant Protein (C-hIgG2 Fc) (RPES2229)
- SKU:
- RPES2229
Description
IL-22 Recombinant Protein (C-hIgG2 Fc)
Interleukin-22(IL-22) is a member of a group of the IL-10 family; a class of potent mediators of cellular inflammatory responses. DC and T cells are the main producers of IL-22. The IL-22 and IL-10 receptors perform a part in cellular targeting and signal transduction. It can create and manage natural immune responses against bacterial infections, especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 and IL-17 are both required for the adaptive and innate immune systems to work together. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and stomach, similar to IL-10. Binding to a cell-surface complex comprised of IL-22R1 and IL-10R2 receptor chains activates biological activity of IL-22. The IL-22 biological activity is controlled by a soluble binding protein, IL-22BP. The IL-22BP and the extracellular region of IL-22R1 have a similar sequence. The pro-inflammatory versus tissue-protective activities of IL-22 are sometimes directed by cytokine IL-17A.IL-22 Recombinant Protein (C-hIgG2 Fc) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | IL-22 Recombinant Protein (C-hIgG2 Fc) (RPES2229) |
| Product Code: | RPES2229 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Interleukin-22, IL-22, Cytokine Zcyto18, IL-10-related T-cell-derived-inducible factor, IL-TIF, IL22,IL-D110,IL-TIF,ILTIF,TIFa,TIFIL-23,zcyto18 |
| Accession: | Q9GZX6 |
| Sequence: | Ala34-Ile179 |
| Fusion tag: | C-hIgG2 Fc |
| Activity: | Measured by its ability to induce IL-10 secretion in COLO 205 human colorectal adenocarcinoma cells. The ED50 for this effect is 90.41 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Interleukin-22 is produced by our Mammalian expression system and the target gene encoding Ala34-Ile179 is expressed with a hIgG2 Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 43.4 kDa |
| AP Mol Mass: | 50-62 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Growth Factors & Cytokines |
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