IFNT1 Antibody (PACO34262)
- SKU:
- PACO34262
- Product Type:
- Antibody
- Reactivity:
- Bovine
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | IFNT1 Antibody (PACO34262) |
| Antibody SKU: | PACO34262 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Bovine |
| Immunogen: | Recombinant Bovine Interferon tau-1 protein (24-195AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. |
| Synonyms: | Interferon tau-1 (IFN-tau-1) (Antiluteolysin) (Trophoblast antiluteolytic protein) (Trophoblast protein 1) (TP-1) (Trophoblastin), IFNT1 |
| UniProt Protein Function: | Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P15696 |
| NCBI GenInfo Identifier: | 269973909 |
| NCBI Gene ID: | 317698 |
| NCBI Accession: | NP_001015511.3 |
| UniProt Secondary Accession: | P15696,P15694, Q28126, Q28127, Q28128, Q28191, Q95NE2 |
| UniProt Related Accession: | P15696,P56830, P15696 |
| Molecular Weight: | |
| NCBI Full Name: | interferon tau-2 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | IFNT2 |
| NCBI Official Synonym Symbols: | IFNT; TP-1; IFNT1; IFN-tau-c2 |
| NCBI Protein Information: | interferon tau-2 |
| UniProt Protein Name: | Interferon tau-1 |
| UniProt Synonym Protein Names: | Antiluteolysin; Trophoblast antiluteolytic protein; Trophoblast protein 1; TP-1; Trophoblastin |
| Protein Family: | Interferon |
| UniProt Gene Name: | IFNT1 |
| UniProt Entry Name: |
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