Description
Product Name: | IFNAR2 Polyclonal Antibody |
Product Code: | CAB21462 |
Reactivity: | Human, Mouse, Rat |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human, Mouse, Rat |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:500-1:1000 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
Positive Samples: | HeLa, MCF7, Raji, Mouse liver, Rat liver |
Cellular Location: | Membrane, Secreted, Single-pass type I membrane protein |
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family. Mutations in this gene are associated with Immunodeficiency 45.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 101-243 of human IFNAR2 (NP_997468.1). |
Sequence: | STHEA YVTVL EGFSG NTTLF SCSHN FWLAI DMSFE PPEFE IVGFT NHINV MVKFP SIVEE ELQFD LSLVI EEQSE GIVKK HKPEI KGNMS GNFTY IIDKL IPNTN YCVSV YLEHS DEQAV IKSPL KCTLL PPGQE SESAE SAK |
Synonyms: | IFN-R, IMD45, IFNABR, IFNARB, IFN-R-2, IFN-alpha-REC |
Calculated MW: | 27kDa/37kDa/57kDa |
Observed MW: | 95kDa |