Human ZWILCH Recombinant Protein (RPPB5190)
- SKU:
- RPPB5190
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9H900
Description
| Product Name: | Human ZWILCH Recombinant Protein |
| Product Code: | RPPB5190 |
| Size: | 10µg |
| Species: | Human |
| Target: | ZWILCH |
| Synonyms: | hZwilch, KNTC1AP, Protein zwilch homolog, ZWILCH. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | ZWILCH protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMWERLNC AAEDFYSRLL QKFNEEKKGI RKDPFLYEAD VQVQLISKGQ PNPLKNILNE NDIVFIVEKV PLEKEETSHI EELQSEETAI SDFSTGENVG PLALPVGKAR QLIGLYTMAH NPNMTHLKIN LPVTALPPLW VRCDSSDPEG TCWLGAELIT TNNSITGIVL YVVSCKADKN YSVNLENLKN LHKKRHHLST VTSKGFAQYE LFKSSALDDT ITASQTAIAL DISWSPVDEI LQIPPLSSTA TLNIKVESGE PRGPLNHLYR ELKFLLVLAD GLRTGVTEWL EPLEAKSAVE LVQEFLNDLN KLDGFGDSTK KDTEVETLKH DTAAVDRSVK RLFKVRSDLD FAEQLWCKMS SSVISYQDLV KCFTLIIQSL QRGDIQPWLH SGSNSLLSKL IHQSYHGTMD TVSLSGTIPV QMLLEIGLDK LKKDYISFFI GQELASLNHL EYFIAPSVDI QEQVYRVQKL HHILEILVSC MPFIKSQHEL LFSLTQICIK YYKQNPLDEQ HIFQLPVRPT AVKNLYQSEK PQKWRVEIYS GQKKIKTVWQ LSDSSPIDHL NFHKPDFSEL TLNGSLEERI FFTNMVTCSQ VHFK |
Zwilch Kinetochore Protein which is also known as ZWILCH is a part of the ZWILCH family. ZWILCH is a vital part of the mitotic checkpoint. ZWILCH prevents the cells from exiting mitosis prematurely. ZWILCH is also necessary for the assembly of the dyneindynactin and MAD1-MAD2 complexes onto kinetochores.
ZWILCH Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 614 amino acids (1-591 a.a) and having a molecular mass of 69.6kDa. ZWILCH is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ZWILCH: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Belongs to the ZWILCH family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 15q22.31 Cellular Component: cytosol; kinetochore Molecular Function:protein binding Biological Process: mitotic cell cycle checkpoint; sister chromatid cohesion |
| UniProt Code: | Q9H900 |
| NCBI GenInfo Identifier: | 166228729 |
| NCBI Gene ID: | 55055 |
| NCBI Accession: | Q9H900.2 |
| UniProt Secondary Accession: | Q9H900,Q6N049, Q8N404, Q96SY7, Q9NWG7, B3KVB8, |
| UniProt Related Accession: | Q9H900 |
| Molecular Weight: | 54,224 Da |
| NCBI Full Name: | Protein zwilch homolog |
| NCBI Synonym Full Names: | zwilch kinetochore protein |
| NCBI Official Symbol: | ZWILCH�� |
| NCBI Official Synonym Symbols: | KNTC1AP; hZwilch�� |
| NCBI Protein Information: | protein zwilch homolog |
| UniProt Protein Name: | Protein zwilch homolog |
| Protein Family: | Protein zwilch |
| UniProt Gene Name: | ZWILCH�� |
| UniProt Entry Name: | ZWILC_HUMAN |
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