Human ZNF346 Recombinant Protein (RPPB5185)
- SKU:
- RPPB5185
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UL40
Description
| Product Name: | Human ZNF346 Recombinant Protein |
| Product Code: | RPPB5185 |
| Size: | 20µg |
| Species: | Human |
| Target: | ZNF346 |
| Synonyms: | Zinc finger protein 346, JAZ, Zfp346, ZNF346. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The ASCC1 solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 2mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMEYPAPA TVQAADGGAA GPYSSSELLE GQEPDGVRFD RERARRLWEA VSGAQPVGRE EVEHMIQKNQ CLFTNTQCKV CCALLISESQ KLAHYQSKKH ANKVKRYLAI HGMETLKGET KKLDSDQKSS RSKDKNQCCP ICNMTFSSPV VAQSHYLGKT HAKNLKLKQQ STKVEALHQN REMIDPDKFC SLCHATFNDP VMAQQHYVGK KHRKQETKLK LMARYGRLAD PAVTDFPAGK GYPCKTCKIV LNSIEQYQAH VSGFKHKNQS PKTVASSLGQ IPMQRQPIQK DSTTLED |
ZNF346 is a nucleolar, zinc finger protein which specially binds to double-stranded RNA or RNA/DNA fusions, instead of DNA alone. Zinc finger domains vital for dsRNA binding and essential for its nucleolar localization. ZNF346 takes part in cell growth and survival.
ZNF346 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 317 amino acids (1-294) and having a molecular mass of 35.3 kDa.ZNF346 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ZNF346: Binds to dsRNA and DNA. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nucleolus Chromosomal Location of Human Ortholog: 5q35.2 Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus Molecular Function:protein binding; enzyme binding; zinc ion binding; double-stranded RNA binding Biological Process: positive regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UL40 |
| NCBI GenInfo Identifier: | 74735051 |
| NCBI Gene ID: | 23567 |
| NCBI Accession: | Q9UL40.1 |
| UniProt Secondary Accession: | Q9UL40,Q68CV9, Q6ZMW1, B7Z367, |
| UniProt Related Accession: | Q9UL40 |
| Molecular Weight: | 294 |
| NCBI Full Name: | Zinc finger protein 346 |
| NCBI Synonym Full Names: | zinc finger protein 346 |
| NCBI Official Symbol: | ZNF346�� |
| NCBI Official Synonym Symbols: | JAZ; Zfp346�� |
| NCBI Protein Information: | zinc finger protein 346; just another zinc finger protein; double-stranded RNA-binding zinc finger protein JAZ |
| UniProt Protein Name: | Zinc finger protein 346 |
| UniProt Synonym Protein Names: | Just another zinc finger protein |
| Protein Family: | Zinc finger protein |
| UniProt Gene Name: | ZNF346�� |
| UniProt Entry Name: | ZN346_HUMAN |
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