Enzymes Recombinant Proteins

Human YWHAG Recombinant Protein (RPPB2684)

(No reviews yet) Write a Review
SKU:
RPPB2684

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human YWHAG Recombinant Protein
Product Code:RPPB2684
Size:25µg
Species:Human
Target:YWHAG
Synonyms:14-3-3 protein gamma, Protein kinase C inhibitor protein 1, KCIP-1, YWHAG, Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:YWHAG solution containing 20mM Tris 7.5.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MVDREQLVQK ARLAEQAERY DDMAAAMKNV TELNEPLSNE ERNLLSVAYK NVVGARRSSW RVISSIEQKT SADGNEKKIE MVRAYREKIE KELEAVCQDV LSLLDNYLIK NCSETQYESK VFYLKMKGDY YRYLAEVATG EKRATVVESS EKAYSEAHEI SKEHMQPTHP IRLGLALNYS VFYYEIQNAP EQACHLAKTA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD DGGEGNN

The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms that have been identified in mammals. The 14-3-3gamma, a subtype of the 14-3-3 family of proteins, was thought to be brain and neuron-specific. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways.

YWHAG Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 247 amino acids (1-247) and having a molecular mass of 28 kDa. YWHAG is purified by proprietary chromatographic techniques.

UniProt Protein Function:14-3-3 gamma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Interacts with SAMSN1. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with PKA-phosphorylated AANAT. Highly expressed in brain, skeletal muscle, and heart. Belongs to the 14-3-3 family.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: cytoplasmic vesicle membrane; cytosol; focal adhesion; membrane

Molecular Function:insulin-like growth factor receptor binding; protein binding; protein kinase C binding

Biological Process: G2/M transition of mitotic cell cycle; regulation of neuron differentiation; regulation of synaptic plasticity

NCBI Summary:This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
UniProt Code:P61981
NCBI GenInfo Identifier:48428721
NCBI Gene ID:7532
NCBI Accession:P61981.2
UniProt Secondary Accession:P61981,O70457, P35214, Q6FH52, Q9UDP2, Q9UN99,
UniProt Related Accession:P61981
Molecular Weight:28,303 Da
NCBI Full Name:14-3-3 protein gamma
NCBI Synonym Full Names:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
NCBI Official Symbol:YWHAG��
NCBI Official Synonym Symbols:PPP1R170; 14-3-3GAMMA��
NCBI Protein Information:14-3-3 protein gamma
UniProt Protein Name:14-3-3 protein gamma
UniProt Synonym Protein Names:Protein kinase C inhibitor protein 1; KCIP-1
Protein Family:14-3-3 protein
UniProt Gene Name:YWHAG��
UniProt Entry Name:1433G_HUMAN
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P61981
Research Area:
Enzymes
View AllClose

Related Products