Cytokines Recombinant Proteins
Human WISP1 Recombinant Protein (RPPB1094)
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- SKU:
- RPPB1094
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95388
- Research Area:
- Cytokines
Description
| Product Name: | Human WISP1 Recombinant Protein |
| Product Code: | RPPB1094 |
| Size: | 10µg |
| Species: | Human |
| Target: | WISP1 |
| Synonyms: | WNT1 Inducible Signaling Pathway Protein 1, CCN Family Member 4, CCN4, Wnt-1 Inducible, Signaling Pathway Protein 1, WNT1 Induced Secreted Protein 1, Wnt-1-Induced Secreted Protein, CTC-458A3.8, WISP1tc, WISP1c, WISP1i, WISP-1, WISP1. |
| Source: | HEK293 Cells |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | WISP1 protein was lyophilized from a 0.2�m filtered solution in PBS. |
| Solubility: | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE.� |
| Amino Acid Sequence: | TALSPAPTTMDFTPAPLEDTSSRPQFCKWPCECPPSPPRCPLGVSLITDGCECCKMCAQQLGDNCTEAAICDPHRGLYCDYSGDRPRYAIGVCAQVVGVGCVLDGVRYNNGQSFQPNCKYNCTCIDGAVGCTPLCLRVRPPRLWCPHPRRVSIPGHCCEQWVCEDDAKRPRKTAPRDTGAFDAVGEVEAWHRNCIAYTSPWSPCSTSCGLGVSTRISNVNAQCWPEQESRLCNLRPCDVDIHTLIKAGKKCLAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNRCCIPYKSKTIDVSFQCPDGLGFSRQVLWINACFCNLSCRNPNDIFADLESYPDFSEIANHHHHHHHHHH |
WISP1 is a part of a family of cysteine-rich, glycosylated signaling proteins that mediate varied developmental processes. WISP1 is a Downstream regulator in the Wnt/Frizzled-signaling pathway and is linked with cell survival.WISP1weakens p53-mediated apoptosis in response to DNA damage through activation of AKT kinase and up-regulates the anti-apoptotic Bcl-X(L) protein.
WISP1 Human Recombinant produced in Mouse myeloma cell line is a single, glycosylated polypeptide chain containing 355 amino acids (Thr23- Asn367), having a molecular mass of 39.3kDa and fused to a 10 aa His Tag.The WISP1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. |
| NCBI Summary: | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011] |
| UniProt Code: | O95388 |
| NCBI GenInfo Identifier: | 34098393 |
| NCBI Gene ID: | 8840 |
| NCBI Accession: | O95388.1 |
| UniProt Secondary Accession: | O95388,Q5JBS6, Q5JBS7, Q5JBS8, Q9HCS3, A8KAG6, E7EMM5 |
| UniProt Related Accession: | O95388 |
| Molecular Weight: | 21,550 Da |
| NCBI Full Name: | WNT1-inducible-signaling pathway protein 1 |
| NCBI Synonym Full Names: | WNT1 inducible signaling pathway protein 1 |
| NCBI Official Symbol: | WISP1�� |
| NCBI Official Synonym Symbols: | CCN4; WISP1c; WISP1i; WISP1tc�� |
| NCBI Protein Information: | WNT1-inducible-signaling pathway protein 1 |
| UniProt Protein Name: | WNT1-inducible-signaling pathway protein 1 |
| UniProt Synonym Protein Names: | CCN family member 4; Wnt-1-induced secreted protein |
| Protein Family: | WNT1-inducible-signaling pathway protein |
| UniProt Gene Name: | WISP1�� |
| UniProt Entry Name: | WISP1_HUMAN |
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