Human VPS29 Recombinant Protein (RPPB5133)
- SKU:
- RPPB5133
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UBQ0
Description
| Product Name: | Human VPS29 Recombinant Protein |
| Product Code: | RPPB5133 |
| Size: | 5µg |
| Species: | Human |
| Target: | VPS29 |
| Synonyms: | Vacuolar protein sorting 29 yeast homolog (S. cerevisiae), DC15, PEP11, DC7, retromer protein, x 007 protein, EC 3.1.3.3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The VPS29 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMMLVLV LGDLHIPHRC NSLPAKFKKL LVPGKIQHIL CTGNLCTKES YDYLKTLAGD VHIVRGDFDE NLNYPEQKVV TVGQFKIGLI HGHQVIPWGD MASLALLQRQ FDVDILISGH THKFEAFEHE NKFYINPGSA TGAYNALETN IIPSFVLMDI QASTVVTYVY QLIGDDVKVE RIEYKKP |
VPS29 is a member of a group of genes coding for vacuolar protein sorting (VPS) proteins which, when functionally damaged, lessens the efficient transfer of vacuolar hydrolases. VPS29 is a late Golgi transmembrane protein that operates as the sorting receptor for soluble vacuolar hydrolases, from the prevacuolar endosome back to the Golgi. Moreover, VPS29 takes part in the creation of the inner shell of the retromer coat for retrograde vesicles parting the prevacuolar compartment.
VPS29 Human Recombinant produced in E. coli is a single polypeptide chain containing 207 amino acids (1-182) and having a molecular mass of 23.2kDa.VPS29 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | VPS29: Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). Belongs to the VPS29 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein phosphatase, Ser/Thr (non-receptor); Vesicle; EC 3.1.3.3 Chromosomal Location of Human Ortholog: 12q24 Cellular Component: intracellular membrane-bound organelle; retromer complex; cytoplasm; late endosome; early endosome; endosome membrane; cytosol; endosome Molecular Function:protein binding; zinc ion binding; protein transporter activity Biological Process: intracellular protein transport; retrograde transport, endosome to Golgi |
| NCBI Summary: | This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q9UBQ0 |
| NCBI GenInfo Identifier: | 25453325 |
| NCBI Gene ID: | 51699 |
| NCBI Accession: | Q9UBQ0.1 |
| UniProt Secondary Accession: | Q9UBQ0,Q502Y5, Q6FIF8, Q6IAH3, Q9H0W0, Q9NRP1, Q9NRU7 |
| UniProt Related Accession: | Q9UBQ0 |
| Molecular Weight: | 20,927 Da |
| NCBI Full Name: | Vacuolar protein sorting-associated protein 29 |
| NCBI Synonym Full Names: | vacuolar protein sorting 29 homolog (S. cerevisiae) |
| NCBI Official Symbol: | VPS29�� |
| NCBI Official Synonym Symbols: | DC7; DC15; PEP11�� |
| NCBI Protein Information: | vacuolar protein sorting-associated protein 29; hVPS29; PEP11 homolog; x 007 protein; retromer protein; vesicle protein sorting 29; vacuolar sorting protein VPS29/PEP11 |
| UniProt Protein Name: | Vacuolar protein sorting-associated protein 29 |
| UniProt Synonym Protein Names: | PEP11 homolog; Vesicle protein sorting 29 |
| Protein Family: | Vacuolar protein sorting-associated protein |
| UniProt Gene Name: | VPS29�� |
| UniProt Entry Name: | VPS29_HUMAN |
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