Growth Factors & Cytokines Recombinant Proteins

Human VEGF Recombinant Protein (RPPB1066)

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SKU:
RPPB1066
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P15692
Research Area:
Growth Factors & Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human VEGF Recombinant Protein
Product Code:RPPB1066
Size:10µg
Species:Human
Target:VEGF
Synonyms:Vascular endothelial growth factor A, VEGF-A, Vascular permeability factor, VPF, VEGF, MGC70609.
Source:Pichia Pastoris
Physical Appearance:Sterile Filtered colorless liquid formulation.
Formulation:The protein contains 20mM Phosphate- Buffered Saline, pH 7.4.
Stability:Vascular Endothelial Growth Factor Human although stable at 15°C for 2 weeks, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Biological Activity:Determined by its ability to stimulate 3H-Thymidine incorporation in human umbilical vein endothelial cells, the ED50 for this effect was found to be 2-6ng/ml.

Vascular endothelial growth factor is an important signaling protein involved in both vasculogenesis and angiogenesis. As its name implies, VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells ). VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF is also a vasodilator and increases microvascular permeability and was originally referred to as vascular permeability factor.Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy.

Vascular Endothelial Growth Factor Human Recombinant produced in Yeast is a double, glycosylated, polypeptide chain containing 165 amino acids and having a molecular mass of 42 kDa.

UniProt Protein Function:Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
NCBI Summary:This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P15692
NCBI GenInfo Identifier:17380528
NCBI Gene ID:7422
NCBI Accession:P15692.2
UniProt Secondary Accession:P15692,O60720, O75875, Q074Z4, Q16889, B5BU86, H0Y2S8 H0Y407, H0Y414, H0Y462, H0Y8N2, H3BLW7,
UniProt Related Accession:P15692
Molecular Weight:34,406 Da
NCBI Full Name:Vascular endothelial growth factor A
NCBI Synonym Full Names:vascular endothelial growth factor A
NCBI Official Symbol:VEGFA��
NCBI Official Synonym Symbols:VPF; VEGF; MVCD1��
NCBI Protein Information:vascular endothelial growth factor A; vascular permeability factor
UniProt Protein Name:Vascular endothelial growth factor A
UniProt Synonym Protein Names:Vascular permeability factor; VPF
Protein Family:VEGF coregulated chemokine
UniProt Gene Name:VEGFA��
UniProt Entry Name:VEGFA_HUMAN
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