Human VAPA Recombinant Protein (RPPB5110)
- SKU:
- RPPB5110
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9P0L0
Description
| Product Name: | Human VAPA Recombinant Protein |
| Product Code: | RPPB5110 |
| Size: | 25µg |
| Species: | Human |
| Target: | VAPA |
| Synonyms: | hVAP-33, VAP-33, VAP-A, VAP33, Vesicle-associated membrane protein-associated protein A, VAMP-associated protein A, VAMP-A, 33 kDa VAMP-associated protein, VAPA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | VAPA solution containing 20mM Tris pH-8, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | RGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMAS ASGAMAKHEQ ILVLDPPTDL KFKGPFTDVV TTNLKLRNPS DRKVCFKVKT TAPRRYCVRP NSGIIDPGST VTVSVMLQPF DYDPNEKSKH KFMVQTIFAP PNTSDMEAVW KEAKPDELMD SKLRCVFEMP NENDKLNDME PSKAVPLNAS KQDGPMPKPH SVSLNDTETR KLMEECKRLQ GEMMKLSEEN RHLRDEGLRL RKVAHSDKPG STSTASFRDN VTSP |
VAPA is involved in vesicle traficking. VAPA is a type IV membrane protein. It is localized in the plasma membrane and intracellular vesicles. VAPA is related with the cytoskeleton. VAPA functions membrane fusion, protein complex assembly and cell motility. VAPA is an essential regulator both of the subcellular localization of protrudin and of its ability to stimulate neurite outgrowth.
VAPA Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 264 amino acids (1-227 a.a.) and having a molecular mass of 29.8 kDa. VAPA is fused to 37 amino acid His Tag and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | VAPA: May play a role in vesicle trafficking. Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Membrane protein, integral Chromosomal Location of Human Ortholog: 18p11.22 Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; perinuclear region of cytoplasm; plasma membrane; tight junction; vesicle Molecular Function:FFAT motif binding; microtubule binding; protein binding; protein domain specific binding; protein heterodimerization activity; signal transducer activity Biological Process: cell death; endoplasmic reticulum organization and biogenesis; ER to Golgi vesicle-mediated transport; neurite development; positive regulation of I-kappaB kinase/NF-kappaB cascade; sphingolipid biosynthetic process |
| NCBI Summary: | The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9P0L0 |
| NCBI GenInfo Identifier: | 122066680 |
| NCBI Gene ID: | 9218 |
| NCBI Accession: | Q9P0L0.3 |
| UniProt Secondary Accession: | Q9P0L0,O75453, Q5U0E7, Q9UBZ2, A6NDZ0, D3DUI3, |
| UniProt Related Accession: | Q9P0L0 |
| Molecular Weight: | 32,614 Da |
| NCBI Full Name: | Vesicle-associated membrane protein-associated protein A |
| NCBI Synonym Full Names: | VAMP associated protein A |
| NCBI Official Symbol: | VAPA�� |
| NCBI Official Synonym Symbols: | VAP-A; VAP33; VAP-33; hVAP-33�� |
| NCBI Protein Information: | vesicle-associated membrane protein-associated protein A |
| UniProt Protein Name: | Vesicle-associated membrane protein-associated protein A |
| UniProt Synonym Protein Names: | 33 kDa VAMP-associated protein; VAP-33 |
| Protein Family: | Virulence-associated protein |
| UniProt Gene Name: | VAPA�� |
| UniProt Entry Name: | VAPA_HUMAN |
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