Human USP15 Recombinant Protein (RPPB5096)
- SKU:
- RPPB5096
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y4E8
Description
| Product Name: | Human USP15 Recombinant Protein |
| Product Code: | RPPB5096 |
| Size: | 10µg |
| Species: | Human |
| Target: | USP15 |
| Synonyms: | Ubiquitin Specific Peptidase 15, Ubiquitin Carboxyl-Terminal Hydrolase 15, Deubiquitinating Enzyme 15, Ubiquitin-Specific-Processing Protease 15, Ubiquitin Specific Protease 15, Ubiquitin Thiolesterase 15, KIAA0529, UNPH4, UNPH-2, EC 3.4.19.12, EC 3.1.2.15. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The USP15 solution contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAEGGAA DLDTQRSDIA TLLKTSLRKG DTWYLVDSRW FKQWKKYVGF DSWDKYQMGD QNVYPGPIDN SGLLKDGDAQ SLKEHLIDEL DYILLPTEGW NKLVSWYTLM EGQEPIARKV VEQGMFVKHC KVEVYLTELK LCENGNMNNV VTRRFSKADT IDTIEKEIRK IFSIPDEKET RLWNKYMSNT FEPLNKPDST IQDAGLYQGQ VLVIEQKNED GTWPRGPSTP KKPLEQSC |
USP15 belongs to the ubiquitin specific protease (USP) family of deubiquitinating enzymes which has a vital role in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. USP15 connects with the COP9 signalosome, and takes part in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms of this gene are known, and a pseudo gene of USP15 is sited on the long arm of chromosome 2.
USP15 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 258 amino acids (1-235) and having a molecular mass of 29.5kDa.USP15 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | USP15: Protease that degrades 'Lys-48'-linked polyubiquitin chains. Protects target proteins against proteasomal degradation. Protects APC and human papillomavirus type 16 protein E6 against degradation via the ubiquitin proteasome pathway. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Ubiquitin-specific protease; Protease; EC 3.4.19.12; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 12q14 Cellular Component: cytoplasm; nucleus Molecular Function:cysteine-type endopeptidase activity; identical protein binding; protein binding; SMAD binding; transforming growth factor beta receptor binding; ubiquitin-specific protease activity Biological Process: BMP signaling pathway; protein deubiquitination; transforming growth factor beta receptor signaling pathway |
| NCBI Summary: | This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2. [provided by RefSeq, Nov 2011] |
| UniProt Code: | Q9Y4E8 |
| NCBI GenInfo Identifier: | 28381406 |
| NCBI Gene ID: | 9958 |
| NCBI Accession: | Q9Y4E8.3 |
| UniProt Secondary Accession: | Q9Y4E8,Q08AL5, Q9H8G9, Q9HCA6, Q9UNP0, Q9Y5B5, |
| UniProt Related Accession: | Q9Y4E8 |
| Molecular Weight: | 27,094 Da |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 15 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 15 |
| NCBI Official Symbol: | USP15�� |
| NCBI Official Synonym Symbols: | UNPH4; UNPH-2�� |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 15 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 15 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15; Unph-2; Unph4 |
| UniProt Gene Name: | USP15�� |
| UniProt Entry Name: | UBP15_HUMAN |
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