Enzymes Recombinant Proteins
Human UPP1 Recombinant Protein (RPPB2407)
- SKU:
- RPPB2407
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q16831
- Research Area:
- Enzymes
Description
| Product Name: | Human UPP1 Recombinant Protein |
| Product Code: | RPPB2407 |
| Size: | 10µg |
| Species: | Human |
| Target: | UPP1 |
| Synonyms: | UP, UPASE, UPP, UrdPase 1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | UPP1 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 0.2M NaCl and 40% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF GDVKFVCVGG SPSRMKAFIR CVGAELGLDC PGRDYPNICA GTDRYAMYKV GPVLSVSHGM GIPSISIMLH ELIKLLYYAR CSNVTIIRIG TSGGIGLEPG TVVITEQAVD TCFKAEFEQI VLGKRVIRKT DLNKKLVQEL LLCSAELSEF TTVVGNTMCT LDFYEGQGRL DGALCSYTEK DKQAYLEAAY AAGVRNIEME SSVFAAMCSA CGLQAAVVCV TLLNRLEGDQ ISSPRNVLSE YQQRPQRLVS YFIKKKLSKA |
UPP1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate which are used as carbon and energy sources or in the release of pyrimidine bases for nucleotide synthesis. UPP1 is part of the family of glycosyltransferases, specifically the pentosyltransferases. Pyrimidine nucleoside phosphorylases add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA.
UPP1 Human Recombinant protein produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 330 amino acids (1-310) and having a molecular mass of 29.3 kDa. UPP1 is fused to a 20 amino acid His Tag at N-terminus and is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UPP1: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - other enzymes; Nucleotide Metabolism - pyrimidine; EC 2.4.2.3; Transferase Chromosomal Location of Human Ortholog: 7p12.3 Cellular Component: cytosol Molecular Function:uridine phosphorylase activity Biological Process: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage |
| NCBI Summary: | The 2 known types of pyrimidine nucleoside phosphorylases, uridine phosphorylase (UP; EC 2.4.2.3) and thymidine phosphorylase (TP; EC 2.4.2.4), in the presence of orthophosphate, catalyze the reversible phosphorolysis of uridine and thymidine or deoxyuridine, respectively, to free bases and ribose-1-phosphate or deoxyribose-1-phosphate. Pyrimidine nucleoside phosphorylases can add ribose or deoxyribose to pyrimidine bases to form nucleosides that can be incorporated into RNA or DNA (Watanabe and Uchida, 1995 [PubMed 7488099]).[supplied by OMIM, Aug 2009] |
| UniProt Code: | Q16831 |
| NCBI GenInfo Identifier: | 2494059 |
| NCBI Gene ID: | 7378 |
| NCBI Accession: | Q16831.1 |
| UniProt Secondary Accession: | Q16831,Q15362, D3DVM4, |
| UniProt Related Accession: | Q16831 |
| Molecular Weight: | 3,694 Da |
| NCBI Full Name: | Uridine phosphorylase 1 |
| NCBI Synonym Full Names: | uridine phosphorylase 1 |
| NCBI Official Symbol: | UPP1�� |
| NCBI Official Synonym Symbols: | UP; UPP; UPASE; UDRPASE�� |
| NCBI Protein Information: | uridine phosphorylase 1 |
| UniProt Protein Name: | Uridine phosphorylase 1 |
| Protein Family: | Uridine phosphorylase |
| UniProt Gene Name: | UPP1�� |
| UniProt Entry Name: | UPP1_HUMAN |
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