Human UPK3A Recombinant Protein (RPPB5087)
- SKU:
- RPPB5087
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O75631
Description
| Product Name: | Human UPK3A Recombinant Protein |
| Product Code: | RPPB5087 |
| Size: | 10µg |
| Species: | Human |
| Target: | UPK3A |
| Synonyms: | Uroplakin 3A, UPK3, UPIII, Uroplakin III, UP3A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | UPK3A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 150mM NaCl, 2mM DTT and 20% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMVNLQP QLASVTFATN NPTLTTVALE KPLCMFDSKE ALTGTHEVYL YVLVDSAISR NASVQDSTNT PLGSTFLQTE GGRTGPYKAV AFDLIPCSDL PSLDAIGDVS KASQILNAYL VRVGANGTCL WDPNFQGLCN PPLSAATEYR FKYVLVNMST GLVEDQTLWS DPIRTNQLTP YSTIDTWPGR RSGG |
UPK3A is a member of the uroplakin-3 family. Uroplakins (UP) which are transmembrane proteins are important components of the urothelium that pass the lipid bilayer once (UPII, UPIIIa, and UPIIIb) or four times (UPIa and UPIb; both members of the "tetraspanin" family). All hold great luminal/extracellular domains, but only UPIIIa and UPIIIb have significant cytoplasmic shares in their C-termini. UPK3A is an extremely specific and moderately sensitive immunohistochemical marker for primary and metastatic urothelial carcinomas. Alterations in this gene are related to renal adysplasia.
UPK3A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 214 amino acids (19-207 a.a.) and having a molecular mass of 23.1kDa.UPK3A is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | UPK3A: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. Defects in UPK3A are a cause of renal adysplasia (RADYS); also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy. Belongs to the uroplakin-3 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 22q13.31 Cellular Component: endoplasmic reticulum membrane; apical plasma membrane; integral to membrane Biological Process: epithelial cell differentiation; urinary bladder development; water transport; urea transport; cell morphogenesis; sodium ion homeostasis; kidney development; potassium ion homeostasis Disease: Renal Hypodysplasia/aplasia 1 |
| NCBI Summary: | This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009] |
| UniProt Code: | O75631 |
| NCBI GenInfo Identifier: | 266456217 |
| NCBI Gene ID: | 7380 |
| NCBI Accession: | NP_001161046.1 |
| UniProt Related Accession: | O75631 |
| Molecular Weight: | |
| NCBI Full Name: | uroplakin-3a isoform 2 |
| NCBI Synonym Full Names: | uroplakin 3A |
| NCBI Official Symbol: | UPK3A�� |
| NCBI Official Synonym Symbols: | UP3A; UPK3; UPIII; UPIIIA�� |
| NCBI Protein Information: | uroplakin-3a |
| UniProt Protein Name: | Uroplakin-3a |
| UniProt Synonym Protein Names: | Uroplakin III |
| UniProt Gene Name: | UPK3A�� |
| UniProt Entry Name: | UPK3A_HUMAN |
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