Immunology Recombinant Proteins
Human ULBP2/N2DL-2 Recombinant Protein (RPES0255)
- SKU:
- RPES0255
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
Human ULBP2/N2DL-2 Recombinant Protein
NKG2D ligand 2; also known as N2DL-2; NKG2DL2; ALCAN-alpha; Retinoic acid early transcript 1H; UL16-binding protein 2; ULBP2 and N2DL2; is cell membrane protein which belongs to the MHC class I family. ULBP2 / N2DL-2 is expressed in various types of cancer cell lines and in the fetus; but not in normal tissues. ULBP2 / N2DL-2 is a ligand for the NKG2D receptor; together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells; resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2; STAT5; ERK and PI3K kinase/Akt signal transduction pathway.
| Product Name: | Human ULBP2/N2DL-2 Recombinant Protein (RPES0255) |
| Product Code: | RPES0255 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | NKG2D Ligand 2, N2DL-2, NKG2DL2, ALCAN-Alpha, Retinoic Acid Early Transcript 1H, UL16-Binding Protein 2, ULBP2, N2DL2, RAET1H |
| Accession: | Q9BZM5 |
| Sequence: | Met 1-Ser 217 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human ULBP2 (Q9BZM5) (Met 1-Ser 217);without the pro peptide; w was fused with the Fc region of human IgG1 at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 48.7 kDa |
| AP Mol Mass: | 58 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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