Human UGT1A1 / UDP-glucuronosyltransferase 1-1 ELISA Kit

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SKU:
HUFI01190
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
P22309
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
UGT1A1, UDP-glucuronosyltransferase 1-1, UDPGT 1-1, bilirubin UDP-glucuronosyltransferase 1-1, UDP glucuronosyltransferase 1 family, polypeptide A1, UGT1*1, UGT1-01, UGT1.1, UDP-glucuronosyltransferase 1A1, Bilirubin-specific UDPGT isozyme 1, hUG-BR1
Reactivity:
Human
Research Area:
Cell Biology

Description

Human UGT1A1 / UDP-glucuronosyltransferase 1-1 ELISA Kit

UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as hormones and steroids, into water soluble excretable metabolites by changing them to urea. UGT1A1 cleaves bile salts, and the most common substrates are bilirubin and simple phenols, flavones, and C18 steroids. UGT1A1 defects can result in a variety of diseases including Crigler-Najjar syndrome types I and II as well as Gilbert syndrome. UGT1A1 is also important for acetaminophen metabolism and metapathway biotransformation via its associated pathways.

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