Enzymes Recombinant Proteins

Human UGP2 Recombinant Protein (RPPB2403)

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SKU:
RPPB2403
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16851
Research Area:
Enzymes

Description

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Product Name:Human UGP2 Recombinant Protein
Product Code:RPPB2403
Size:10µg
Species:Human
Target:UGP2
Synonyms:UDP-Glucose Pyrophosphorylase 2,UDP-Glucose Pyrophosphorylase 1, EC 2.7.7.9, UGPP2, UDPGP, UGP1, UTP--Glucose-1-Phosphate Uridylyltransferase 2Uridyl Diphosphate Glucose Pyrophosphorylase-1, Uridyl Diphosphate Glucose Pyrophosphorylase 2, UTP--Glucose-1-Phosphate Uridylyltransferase , UTP-Glucose-1-Phosphate, Uridyltransferase, UDP-Glucose Pyrophosphorylase , UDP-Glucose Diphosphorylase, UGPase 2, UDPGP2, PHC379, UGPase, UGPP1, UDPG.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:UGP2 protein solution (0.25mg/ml) containing Phosphate buffered saline (pH7.4) and 20% glycerol, 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSRFVQD LSKAMSQDGA SQFQEVIRQE LELSVKKELE KILTTASSHE FEHTKKDLDG FRKLFHRFLQ EKGPSVDWGK IQRPPEDSIQ PYEKIKARGL PDNISSVLNK LVVVKLNGGL GTSMGCKGPK SLIGVRNENT FLDLTVQQIE HLNKTYNTDV PLVLMNSFNT DEDTKKILQK YNHCRVKIYT FNQSRYPRIN KESLLPVAKD VSYSGENTEA WYPPGHGDIY ASFYNSGLLD TFIGEGKEYI FVSNIDNLGA TVDLYILNHL MNPPNGKRCE FVMEVTNKTR ADVKGGTLTQ YEGKLRLVEI AQVPKAHVDE FKSVSKFKIF NTNNLWISLA AVKRLQEQNA IDMEIIVNAK TLDGGLNVIQ LETAVGAAIK SFENSLGINV PRSRFLPVKT TSDLLLVMSN LYSLNAGSLT MSEKREFPTV PLVKLGSSFT KVQDYLRRFE SIPDMLELDH LTVSGDVTFG KNVSLKGTVI IIANHGDRID IPPGAVLENK IVSGNLRILD H

UDP-Glucose Pyrophosphorylase 2, also known as UGP2� is an essential� intermediary in mammalian carbohydrate interconversions. UGP2 transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucoseand MgPPi. UDP-glucose is a direct precursor of glycogen in the liver andmuscle tissue, moreover in lactating mammary gland it is converted toUDP-galactose which is next converted to lactose.

UGP2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 531 amino acids (1-508 a.a) and having a molecular mass of 59.3kDa.UGP2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:UGP2: Plays a central role as a glucosyl donor in cellular metabolic pathways. Belongs to the UDPGP type 1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; EC 2.7.7.9; TransferaseChromosomal Location of Human Ortholog: 2p14-p13Cellular Component: cytoplasm; cytosol; nucleusMolecular Function: identical protein binding; protein binding; UTP:glucose-1-phosphate uridylyltransferase activityBiological Process: glycogen biosynthetic process; glycogen metabolic process; UDP-glucuronate biosynthetic process
UniProt Protein Details:
NCBI Summary:The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q16851
NCBI GenInfo Identifier:48255968
NCBI Gene ID:7360
NCBI Accession:NP_001001521
UniProt Secondary Accession:Q16851
UniProt Related Accession:Q16851
Molecular Weight:56kDa
NCBI Full Name:UTP--glucose-1-phosphate uridylyltransferase isoform b
NCBI Synonym Full Names:UDP-glucose pyrophosphorylase 2
NCBI Official Symbol:UGP2��
NCBI Official Synonym Symbols:UDPG; UGP1; UDPGP; UGPP1; UGPP2; UDPGP2; pHC379��
NCBI Protein Information:UTP--glucose-1-phosphate uridylyltransferase
UniProt Protein Name:UTP--glucose-1-phosphate uridylyltransferase
UniProt Synonym Protein Names:UDP-glucose pyrophosphorylase; UDPGP; UGPase
Protein Family:
UniProt Gene Name:UGP2��
UniProt Entry Name:UGPA_HUMAN
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