Human UBR1 ELISA Kit

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SKU:
HUFI01873
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q8IWV7
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
UBR1, Ubiquitin-protein ligase E3-alpha-I, N-recognin-1, E3 ubiquitin-protein ligase UBR1, N-recognin-1
Reactivity:
Human
Research Area:
Signal Transduction

Description

Human UBR1 ELISA Kit

UBR1 (Ubiquitin Protein Ligase E3 Component N-Recognin 1) is a E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. UBR1 binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain, which leads to eventual proteolytic degradation. Mutations in UBR1 have been associated with diseases including Urethral obstruction sequence, and Johanson-Blizzard syndrome.

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