Enzymes Recombinant Proteins

Human UBE2R2 Recombinant Protein (RPPB2389)

(No reviews yet) Write a Review
SKU:
RPPB2389

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human UBE2R2 Recombinant Protein
Product Code:RPPB2389
Size:10µg
Species:Human
Target:UBE2R2
Synonyms:CDC34B, E2-CDC34B, UBC3B, Ubiquitin carrier protein R2, Ubiquitin-conjugatingenzyme E2-CDC34B, Ubiquitin-protein ligase R2, Ubiquitin-conjugating enzyme E2R2, EC 6.3.2.19.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:UBE2R2 protein solution (0.25mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMAQQQMT SSQKALMLEL KSLQEEPVEG FRITLVDESD LYNWEVAIFGPPNTLYEGGY FKAHIKFPID YPYSPPTFRF LTKMWHPNIY ENGDVCISIL HPPVDDPQSG ELPSERWNPTQNVRTILLSV ISLLNEPNTF SPANVDASVM FRKWRDSKGK DKEYAEIIRK QVSATKAEAE KDGVKVPTTL AEYCIKTKVP SNDNSSDLLYDDLYDDDIDD EDEEEEDADC YDDDDSGNEE S

Ubiquitin-conjugatingenzyme E2 R2 (UBE2R2) is a member of the ubiquitin-conjugatingenzyme family. Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thrprotein kinase implicated in cell growth and transformation. This protein is a protein similar to theE2 ubiquitin conjugating enzymeUBC3/CDC34. Studies proposethat CK2-dependent phosphorylation of this ubiquitin-conjugating enzymefunctions by regulating beta-TrCPsubstrate recognition and induces itsinteraction with beta-TrCP, enhancing beta-catenin degradation. UBE2R2 receives ubiquitin from the E1complex and catalyzes its covalent attachment to other proteins. In vitro catalyzesmonoubiquitination and 'Lys-48'-linked polyubiquitination. UBE2R2 may be implicatedin degradation of katenin. Among the diseases associated with UBE2R2 are cblc,and herpes simplex.

UBE2R2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 261 amino acids (1-238 a.a) and having a molecular mass of 29.6kDa (Molecular size on SDS-PAGE will appear higher).UBE2R2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:UBC3B: an E2 ubiquitin conjugating enzyme similar to UBC3/CDC34. Phosphorylation of UBC3B by CK2 induces its interaction with beta-TrCP, regulating beta-TrCP substrate recognition and enhancing beta-catenin degradation.
UniProt Protein Details:

Protein type:EC 6.3.2.19; Ubiquitin ligase; Ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: cytoplasm

Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: protein monoubiquitination; proteasomal ubiquitin-dependent protein catabolic process

NCBI Summary:Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. [provided by RefSeq, Jul 2008]
UniProt Code:Q712K3
NCBI GenInfo Identifier:74749761
NCBI Gene ID:54926
NCBI Accession:Q712K3.1
UniProt Secondary Accession:Q712K3,Q9NX64, D3DRL5,
UniProt Related Accession:Q712K3
Molecular Weight:238
NCBI Full Name:Ubiquitin-conjugating enzyme E2 R2
NCBI Synonym Full Names:ubiquitin-conjugating enzyme E2R 2
NCBI Official Symbol:UBE2R2��
NCBI Official Synonym Symbols:UBC3B; CDC34B; E2-CDC34B��
NCBI Protein Information:ubiquitin-conjugating enzyme E2 R2; ubiquitin-protein ligase R2; ubiquitin carrier protein R2; ubiquitin-conjugating enzyme UBC3B; ubiquitin-conjugating enzyme E2-CDC34B
UniProt Protein Name:Ubiquitin-conjugating enzyme E2 R2
UniProt Synonym Protein Names:Ubiquitin carrier protein R2; Ubiquitin-conjugating enzyme E2-CDC34B; Ubiquitin-protein ligase R2
Protein Family:Ubiquitin-conjugating enzyme
UniProt Gene Name:UBE2R2��
UniProt Entry Name:UB2R2_HUMAN
View AllClose

Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q712K3
Research Area:
Enzymes
View AllClose

Related Products