Enzymes Recombinant Proteins
Human UBE2G Recombinant Protein (RPPB2376)
- SKU:
- RPPB2376
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P62253
- Research Area:
- Enzymes
Description
| Product Name: | Human UBE2G Recombinant Protein |
| Product Code: | RPPB2376 |
| Size: | 20µg |
| Species: | Human |
| Target: | UBE2G |
| Synonyms: | E217K, UBC7, UBE2G, Ubiquitin-conjugating enzyme E2 G1, E2ubiquitin-conjugating enzyme G1, E217K, UBC7, Ubiquitin carrier protein G1, Ubiquitin-proteinligase G1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | UBE2G protein solution (0.5mg/ml) containing Phosphatebuffered saline, (pH7.4) 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMTELQSA LLLRRQLAEL NKNPVEGFSA GLIDDNDLYR WEVLIIGPPDTLYEGGVFKA HLTFPKDYPL RPPKMKFITE IWHPNVDKNG DVCISILHEP GEDKYGYEKP EERWLPIHTVETIMISVISM LADPNGDSPA NVDAAKEWRE DRNGEFKRKV ARCVRKSQET AFE |
Protein modification with ubiquitin is an essential cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least 3 classes of enzymes: ubiquitin-activating enzymes (E1s) ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). Ubiquitin-Conjugating Enzyme E2G (UBE2G1) belongs to the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. UE2G1 protein is involved in degradation of muscle-specific proteins.
UBE2G Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 193 amino acids (1-170 a.a) andhaving a molecular mass of 21.9kDa.UBE2G is fusedto a 23 amino acid His-tag at N-terminus & purified by proprietarychromatographic techniques.
| UniProt Protein Function: | UBE2G1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. Belongs to the ubiquitin-conjugating enzyme family. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Ligase; Ubiquitin ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: cytoplasm Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity Biological Process: ubiquitin-dependent protein catabolic process; cellular protein catabolic process |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P62253 |
| NCBI GenInfo Identifier: | 51338681 |
| NCBI Gene ID: | 7326 |
| NCBI Accession: | P62253.3 |
| UniProt Secondary Accession: | P62253,Q99462, B2R7P2, D3DTK0, |
| UniProt Related Accession: | P62253 |
| Molecular Weight: | 170 |
| NCBI Full Name: | Ubiquitin-conjugating enzyme E2 G1 |
| NCBI Synonym Full Names: | ubiquitin-conjugating enzyme E2G 1 |
| NCBI Official Symbol: | UBE2G1�� |
| NCBI Official Synonym Symbols: | UBC7; E217K; UBE2G�� |
| NCBI Protein Information: | ubiquitin-conjugating enzyme E2 G1; ubiquitin-protein ligase G1; ubiquitin carrier protein G1; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast); ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans); ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7) |
| UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 G1 |
| UniProt Synonym Protein Names: | E217K; UBC7; Ubiquitin carrier protein G1; Ubiquitin-protein ligase G1Ubiquitin-conjugating enzyme E2 G1, N-terminally processed |
| Protein Family: | Ubiquitin-conjugating enzyme |
| UniProt Gene Name: | UBE2G1�� |
| UniProt Entry Name: | UB2G1_HUMAN |
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