Enzymes Recombinant Proteins

Human UBE2G Recombinant Protein (RPPB2376)

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SKU:
RPPB2376
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P62253
Research Area:
Enzymes

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human UBE2G Recombinant Protein
Product Code:RPPB2376
Size:20µg
Species:Human
Target:UBE2G
Synonyms:E217K, UBC7, UBE2G, Ubiquitin-conjugating enzyme E2 G1, E2ubiquitin-conjugating enzyme G1, E217K, UBC7, Ubiquitin carrier protein G1, Ubiquitin-proteinligase G1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:UBE2G protein solution (0.5mg/ml) containing Phosphatebuffered saline, (pH7.4) 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMTELQSA LLLRRQLAEL NKNPVEGFSA GLIDDNDLYR WEVLIIGPPDTLYEGGVFKA HLTFPKDYPL RPPKMKFITE IWHPNVDKNG DVCISILHEP GEDKYGYEKP EERWLPIHTVETIMISVISM LADPNGDSPA NVDAAKEWRE DRNGEFKRKV ARCVRKSQET AFE

Protein modification with ubiquitin is an essential cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least 3 classes of enzymes: ubiquitin-activating enzymes (E1s) ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). Ubiquitin-Conjugating Enzyme E2G (UBE2G1) belongs to the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. UE2G1 protein is involved in degradation of muscle-specific proteins.

UBE2G Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 193 amino acids (1-170 a.a) andhaving a molecular mass of 21.9kDa.UBE2G is fusedto a 23 amino acid His-tag at N-terminus & purified by proprietarychromatographic techniques.

UniProt Protein Function:UBE2G1: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4. Belongs to the ubiquitin-conjugating enzyme family.
UniProt Protein Details:

Protein type:EC 6.3.2.19; Ligase; Ubiquitin ligase; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: cytoplasm

Molecular Function:small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity

Biological Process: ubiquitin-dependent protein catabolic process; cellular protein catabolic process

NCBI Summary:The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins. [provided by RefSeq, Jul 2008]
UniProt Code:P62253
NCBI GenInfo Identifier:51338681
NCBI Gene ID:7326
NCBI Accession:P62253.3
UniProt Secondary Accession:P62253,Q99462, B2R7P2, D3DTK0,
UniProt Related Accession:P62253
Molecular Weight:170
NCBI Full Name:Ubiquitin-conjugating enzyme E2 G1
NCBI Synonym Full Names:ubiquitin-conjugating enzyme E2G 1
NCBI Official Symbol:UBE2G1��
NCBI Official Synonym Symbols:UBC7; E217K; UBE2G��
NCBI Protein Information:ubiquitin-conjugating enzyme E2 G1; ubiquitin-protein ligase G1; ubiquitin carrier protein G1; ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast); ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans); ubiquitin-conjugating enzyme E2G 1 (homologous to C. elegans UBC7)
UniProt Protein Name:Ubiquitin-conjugating enzyme E2 G1
UniProt Synonym Protein Names:E217K; UBC7; Ubiquitin carrier protein G1; Ubiquitin-protein ligase G1Ubiquitin-conjugating enzyme E2 G1, N-terminally processed
Protein Family:Ubiquitin-conjugating enzyme
UniProt Gene Name:UBE2G1��
UniProt Entry Name:UB2G1_HUMAN
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