Human UBA3 / NEDD8 E1 ELISA Kit

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SKU:
HUFI00894
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q8TBC4
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
UBA3, NEDD8 E1, APPBP1, NEDD8-activating enzyme E1 catalytic subunit, Ubiquitin-like modifier-activating enzyme 3, Ubiquitin-activating enzyme 3, NEDD8-activating enzyme E1C, Ubiquitin-activating enzyme E1C
Reactivity:
Human
Research Area:
Cell Cycle

Description

Human UBA3 / NEDD8 E1 ELISA Kit

The ubiquitination of proteins is an essential cellular mechanism for targeting aberrant or short-lived proteins for degradation.The ubiquitin-protein ligase enzymes, or E3s, are a group of three enzymes that remove ubiquitins from proteins. UBA3/NEDD8 E1 is an E1 member of the E1 ubiquitin-activating enzyme family. UBA3 binds to AppBp1, an amyloid beta precursor binding protein, to form a heterodimer and then activates NEDD8, a ubiquitin-like protein that controls cell division, signaling, and early development. Class I MHC-mediated antigen processing and presentation, as well as Cytokine Signaling in the Immune System are among UBA3 downstream pathways.

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