Enzymes Recombinant Proteins
Human UBA2 Recombinant Protein (RPPB2362)
- SKU:
- RPPB2362
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UBT2
- Research Area:
- Enzymes
Description
| Product Name: | Human UBA2 Recombinant Protein |
| Product Code: | RPPB2362 |
| Size: | 5µg |
| Species: | Human |
| Target: | UBA2 |
| Synonyms: | Ubiquitin Like Modifier Activating Enzyme 2, Ubiquitin-Like Modifier Activating Enzyme 2, Ubiquitin-Like Modifier-Activating Enzyme 2, Anthracycline-Associated Resistance ARX, Ubiquitin-Like 1-Activating Enzyme E1B, SUMO1 Activating Enzyme Subunit 2, SAE2, Ubiquitin-Activating Enzyme E1 Homolog (Yeast), UBA2, Ubiquitin-Activating Enzyme E1 Homolog, SUMO-1 Activating Enzyme Subunit 2, HRIHFB2115, EC 6.3.2.-, EC 6.3.2, UBLE1B, UBA2, ARX. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | UBA2 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADLMALSRGL PRELAEAVAG GRVLVVGAGG IGCELLKNLV LTGFSHIDLI DLDTIDVSNL NRQFLFQKKH VGRSKAQVAK ESVLQFYPKA NIVAYHDSIM NPDYNVEFFR QFILVMNALD NRAARNHVNR MCLAADVPLI ESGTAGYLGQ VTTIKKGVTE CYECHPKPTQ RTFPGCTIRN TPSEPIHCIV WAKYLFNQLF GEEDADQEVS PDRADPEAAW EPTEAEARAR ASNEDGDIKR ISTKEWAKST GYDPVKLFTK LFKDDIRYLL TMDKLWRKRK PPVPLDWAEV QSQGEETNAS DQQNEPQLGL KDQQVLDVKS YARLFSKSIE TLRVHLAEKG DGAELIWDKD DPSAMDFVTS AANLRMHIFS MNMKSRFDIK SMAGNIIPAI ATTNAVIAGL IVLEGLKILS GKIDQCRTIF LNKQPNPRKK LLVPCALDPP NPNCYVCASK PEVTVRLNVH KVTVLTLQDK IVKEKFAMVA PDVQIEDGKG TILISSEEGE TEANNHKKLS EFGIRNGSRL QADDFLQDYT LLINILHSED LGKDVEFEVV GDAPEKVGPK QAEDAAKSIT NGSDDGAQPS TSTAQEQDDV LIVDSDEEDS SNNADVSEEE RSRKRKLDEK ENLSAKRSRI EQKEELDDVI ALDHHHHHH |
SUMO-activating enzyme subunit 2 (UBA2) belongs to a family of small and related proteins which can be enzymatically attached to a target protein by a post-translational modification process termed sumoylation. UBA2 is conjugated to various molecules in the presence of the SAE1/UBA2 SUMO-activating(E1) enzyme and the UBE2I/Ubc9 SUMO-conjugating(E2) enzyme. UBA2 represents a vital mechanism to protect neurons during episodes of cerebral ischemia.
UBA2 Human Recombinant produced in in Sf9 Baculovirus cells is a single, non-glycosylated polypeptide chain containing 649 amino acids (1-640a.a) and having a molecular mass of 72.3kDa (Migrates at 70-100kDa on SDS-PAGE under reducing conditions). UBA2 is fused to a 6 amino acid His-tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | SAE2: a protein of the ubiquitin-activating E1 family. Acts as a UBL1 E1 ligase. Mediates ATP-dependent activation of UBL1 and formation of a thiolester with a conserved cysteine residue on SAE2. |
| UniProt Protein Details: | Protein type:Ubiquitin ligase; Motility/polarity/chemotaxis; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: 19q12 Cellular Component: nucleoplasm; cytosol; nucleus Molecular Function:SUMO activating enzyme activity; protein binding; protein heterodimerization activity; metal ion binding; enzyme activator activity; transcription factor binding; ATP binding Biological Process: positive regulation of catalytic activity; cellular protein metabolic process; protein sumoylation; SMT3-dependent protein catabolic process; post-translational protein modification |
| NCBI Summary: | Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 (MIM 613294) and UBA2 form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010] |
| UniProt Code: | Q9UBT2 |
| NCBI GenInfo Identifier: | 42559898 |
| NCBI Gene ID: | 10054 |
| NCBI Accession: | Q9UBT2.2 |
| UniProt Secondary Accession: | Q9UBT2,O95605, Q59H87, Q6IBP6, Q9NTJ1, Q9UED2, B3KWB9 |
| UniProt Related Accession: | Q9UBT2 |
| Molecular Weight: | 640 |
| NCBI Full Name: | SUMO-activating enzyme subunit 2 |
| NCBI Synonym Full Names: | ubiquitin-like modifier activating enzyme 2 |
| NCBI Official Symbol: | UBA2�� |
| NCBI Official Synonym Symbols: | ARX; SAE2; HRIHFB2115�� |
| NCBI Protein Information: | SUMO-activating enzyme subunit 2; SUMO1 activating enzyme subunit 2; SUMO-1 activating enzyme subunit 2; ubiquitin-like 1-activating enzyme E1B; anthracycline-associated resistance ARX; ubiquitin-like modifier-activating enzyme 2; UBA2, ubiquitin-activating enzyme E1 homolog |
| UniProt Protein Name: | SUMO-activating enzyme subunit 2 |
| UniProt Synonym Protein Names: | Anthracycline-associated resistance ARX; Ubiquitin-like 1-activating enzyme E1B; Ubiquitin-like modifier-activating enzyme 2 |
| Protein Family: | Ubiquitin-activating enzyme |
| UniProt Gene Name: | UBA2�� |
| UniProt Entry Name: | SAE2_HUMAN |
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