Enzymes Recombinant Proteins
Human TYMP Recombinant Protein (RPPB2360)
- SKU:
- RPPB2360
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P19971
- Research Area:
- Enzymes
Description
| Product Name: | Human TYMP Recombinant Protein |
| Product Code: | RPPB2360 |
| Size: | 20µg |
| Species: | Human |
| Target: | TYMP |
| Synonyms: | Thymidine phosphorylase, Gliostatin, Platelet-derived endothelial cell growth factor, PD-ECGF, TdRPase, TYMP, ECGF1, TP, MNGIE, MEDPS1, MTDPS1, PDECGF, hPD-ECGF. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The TYMP solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MAPPAPGDFS GEGSQGLPDP SPEPKQLPEL IRMKRDGGRL SEADIRGFVA AVVNGSAQGA QIGAMLMAIR LRGMDLEETS VLTQALAQSG QQLEWPEAWR QQLVDKHSTG GVGDKVSLVL APALAACGCK VPMISGRGLG HTGGTLDKLE SIPGFNVIQS PEQMQVLLDQ AGCCIVGQSE QLVPADGILY AARDVTATVD SLPLITASIL SKKLVEGLSA LVVDVKFGGA AVFPNQEQAR ELAKTLVGVG ASLGLRVAAA LTAMDKPLGR CVGHALEVEE ALLCMDGAGP PDLRDLVTTL GGALLWLSGH AGTQAQGAAR VAAALDDGSA LGRFERMLAA QGVDPGLARA LCSGSPAERR QLLPRAREQE ELLAPADGTV ELVRALPLAL VLHELGAGRS RAGEPLRLGV GAELLVDVGQ RLRRGTPWLR VHRDGPALSG PQSRALQEAL VLSDRAPFAA PSPFAELVLP PQQ |
Thymidine phosphorylase precursor (TYMP) is a platelet-derived endothelial cell growth factor that catalyzes the formation of thymine and 2-deoxy-D-ribose-1-phosphate from thymidine and orthophosphate. TYMP is an angiogenic inducer that potently stimulates the growth of endothelial cells and induces chemotaxis. TYMP has a highly restricted target cell specificity acting only on endothelial cells. An increased expression of TYMP is found in a broad array of different solid tumors and inflammatory diseases and is frequently associated with poor prognosis. Mutations in the TYMP gene are linked to mitochondrial neurogastrointestinal encephalomyopathy.
TYMP Human Recombinant fused with a 21 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 493 amino acids (11-482 a.a.) and having a molecular mass of 51.3kDa. The TYMP is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | ECGF1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine; EC 2.4.2.4; Phosphorylase; DNA replication; Transferase; Cytokine; Xenobiotic Metabolism - drug metabolism - other enzymes Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: cytosol Molecular Function:phosphorylase activity; platelet-derived growth factor receptor binding; transferase activity, transferring pentosyl groups Biological Process: DNA replication; mitochondrial genome maintenance; pyrimidine nucleoside catabolic process; pyrimidine nucleoside salvage; pyrimidine nucleotide metabolic process Disease: Mitochondrial Dna Depletion Syndrome 1 (mngie Type) |
| NCBI Summary: | This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P19971 |
| NCBI GenInfo Identifier: | 67477361 |
| NCBI Gene ID: | 1890 |
| NCBI Accession: | P19971.2 |
| UniProt Secondary Accession: | P19971,Q13390, Q8WVB7, A8MW15, H9KVA0, |
| UniProt Related Accession: | P19971 |
| Molecular Weight: | 50,405 Da |
| NCBI Full Name: | Thymidine phosphorylase |
| NCBI Synonym Full Names: | thymidine phosphorylase |
| NCBI Official Symbol: | TYMP�� |
| NCBI Official Synonym Symbols: | TP; ECGF; ECGF1; MNGIE; MEDPS1; MTDPS1; PDECGF; hPD-ECGF�� |
| NCBI Protein Information: | thymidine phosphorylase |
| UniProt Protein Name: | Thymidine phosphorylase |
| UniProt Synonym Protein Names: | Gliostatin; Platelet-derived endothelial cell growth factor; PD-ECGF; TdRPase |
| UniProt Gene Name: | TYMP�� |
| UniProt Entry Name: | TYPH_HUMAN |
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