Human TXNDC17/TRP14/TXNL5 Recombinant Protein (RPES2222)

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SKU:
RPES2222
Product Type:
Recombinant Protein
Species:
Human

Description

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Human TXNDC17/TRP14/TXNL5 Recombinant Protein

A33 antigen, also known as glycoprotein A33, is a single-pass type I membrane protein that is expressed in the normal gastrointestinal epithelium and in 95% of colon cancers. GPA33 contains one C2-like (immunoglobulin-like) domain and one V-type (immunoglobulin-like) domain. The open reading frame encodes a 319-amino acid polypeptide with a putative secretory signal sequence and three possible glycosylation sites. The predicted mature protein has a 213-amino acid extracellular domain, a single transmembrane domain, and a 62-amino acid intracellular tail. Intracellular traffic and recycling to the cell surface appear to be essential for GPA33 function, with their influence on surface density surpassing translational control. GPA33 has become a promising target of immunologic therapy strategies, but its biologic function and potential role in tumorigenesis are unknown. The protein EpCAM and the mRNA gene GA33 are unique and sensitive indicators of Barrett's metaplasia (BM). It may also be involved in cell-cell contact recognition and signalling. Human TXNDC17/TRP14/TXNL5 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

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