Human TSNAX Recombinant Protein (RPPB5031)
- SKU:
- RPPB5031
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q99598
Description
| Product Name: | Human TSNAX Recombinant Protein |
| Product Code: | RPPB5031 |
| Size: | 20µg |
| Species: | Human |
| Target: | TSNAX |
| Synonyms: | TRAX, Translin-associated protein X, Translin-associated factor X. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | TSNAX protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.2M NaCl, 50% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSNKEGS GGFRKRKHDN FPHNQRREGK DVNSSSPVML AFKSFQQELD ARHDKYERLV KLSRDITVES KRTIFLLHRI TSAPDMEDIL TESEIKLDGV RQKIFQVAQE LSGEDMHQFH RAITTGLQEY VEAVSFQHFI KTRSLISMDE INKQLIFTTE DNGKENKTPS SDAQDKQFGT WRLRVTPVDY LLGVADLTGE LMRMCINSVG NGDIDTPFEV SQFLRQVYDG FSFIGNTGPY EVSKKLYTLK QSLAKVENAC YALKVRGSEI PKHMLADVFS VKTEMIDQEE GIS |
TSNAX is a member of translin family. TSNAX particularly interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. TSNAX works in combination with TSN as an endonuclease involves in the activation of the RNA-induced silencing complex (RISC). TSNAX has bipartite nuclear targeting sequences that afford nuclear transport for translin, which lacks any nuclear targeting motifs.
TSNAX Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 313 amino acids (1-290 a.a.) and having a molecular mass of 35kDa.TSNAX is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TSNAX: Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis. Belongs to the translin family. |
| UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 1q42.2 Cellular Component: cytosol; nucleus Molecular Function:DNA binding; protein binding; protein transporter activity; RNA binding Biological Process: RNA-mediated gene silencing |
| NCBI Summary: | This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99598 |
| NCBI GenInfo Identifier: | 6136057 |
| NCBI Gene ID: | 7257 |
| NCBI Accession: | Q99598.1 |
| UniProt Secondary Accession: | Q99598,B1APC6, |
| UniProt Related Accession: | Q99598 |
| Molecular Weight: | 33kDa |
| NCBI Full Name: | Translin-associated protein X |
| NCBI Synonym Full Names: | translin associated factor X |
| NCBI Official Symbol: | TSNAX�� |
| NCBI Official Synonym Symbols: | TRAX�� |
| NCBI Protein Information: | translin-associated protein X |
| UniProt Protein Name: | Translin-associated protein X |
| UniProt Synonym Protein Names: | Translin-associated factor X |
| Protein Family: | Translin-associated protein |
| UniProt Gene Name: | TSNAX�� |
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