Human TSLP Recombinant Protein (RPES0772)

Human TSLP Recombinant Protein

Thymic stromal lymphopoietin (TSLP) is a novel hemopoietic cytokine that promotes B-cell development and has similar effects to IL-7. The human TSLP protein consists of a 28-amino acid (aa) signal sequence and a 131-aa mature domain. Human TSLP has two distinct forms, lfTSLP and sfTSLP, both formed by alternative splicing. lfTSLP is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral mucosa, skin and in salivary glands. Human TSLP has a 43% sequence identity with mouse TSLP in the aa level. TSLP is a cytokine that functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. The TSLP promotes cell proliferation in the myeloid cell line, and it can stimulate asthma or atopic dermatitis responses by directly activating mast cells. TSLP signals cells via the interleukin-7 receptor-alpha chain (IL-7R-alpha), which is also shared with IL-7, in conjunction with the TSLP receptor subunit. Recent studies indicate that TSLP and its receptor are novel therapeutic targets for rheumatoid arthritis, for increased intraarticular TSLP concentrations in patients has caused chemotaxis and activation of arthritogenic T cells. Human TSLP Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.