Human TRPA1 Full-Length Bioactive Membrane Protein (HDFP016)

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SKU:
HDFP016
Product Type:
Recombinant Protein
Protein Type:
Full-Length Bioactive Membrane Protein
Species:
Human
Uniprot:
O75762

Description

system_update_altDatasheet
Product nameHuman TRPA1 full length protein-synthetic nanodisc
Size:10ug
Product SKU:HDFP016
Product CategoryFull Length Transmembrane Proteins
Target:TRPA1
Uniprot:O75762
Description:Human TRPA1 full length protein-synthetic nanodisc
Molecular Weight:The human full length TRPA1 protein has a MW of 127.5 kDa
Protein Family:Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
Protein Pathways:
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Synonyms:ANKTM1; FEPS; FEPS1
Expression System:HEK293
Formulation:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Background:The structure of the protein is highly related to both the protein ankyrin and transmembrane proteins. This protein is activated by a large variety of structurally unrelated electrophilic and non-electrophilic chemical compounds. Electrophilic ligands activate TRPA1 by interacting with critical N-terminal Cys residues in a covalent manner, whereas mechanisms of non-electrophilic ligands are not well determined. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system.
Delivery:In Stock
UsageResearch use only
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