Human TROP2/TACSTD2 Recombinant Protein (RPES3316)
- SKU:
- RPES3316
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human TROP2/TACSTD2 Recombinant Protein
TROP-2, also referred to as tumor associated calcium signal transducer 2 (TACSTD2), GA733-1 or M1S1, is a cell surface glycoprotein highly expressed in a wide variety of epithelial cancers. In contrast, there is little or no expression of Trop-2 in adult somatic tissue. Because it is a cell surface protein that is selectively expressed in tumor cells, Trop-2 is a potential therapeutic target. The cytoplasmic tail of Trop-2 possesses potential serine and tyrosine phosphorylation sites and a phosphatidyl-inositol binding consensus sequence. Trop-2 transduces an intracellular calcium signal, are consistent with the hypothesis that it acts as a cell surface receptor and support a search for a physiological ligand. TROP2 encoding by an intronless gene was originally defined by the monoclonal antibody GA733, and is a member of a family of at least two type I membrane proteins. The other known member is GA733-2, also called EpCAM and TROP1. It has been suggested by studies that the GA733-1 gene was formed by the retroposition of the GA733-2 gene via an mRNA intermediate.
| Product Name: | Human TROP2/TACSTD2 Recombinant Protein (RPES3316) |
| Product Code: | RPES3316 |
| Size: | 100µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | EGP-1,EGP1,GA733-1,GA7331,GP50,M1S1,TACD2,TROP-2,TROP2 |
| Accession: | NP_002344.2 |
| Sequence: | Met 1-Thr 274 |
| Fusion tag: | C-His & Fc |
| Activity: | Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells. When cells are added to coated plates (10µg/ml,100?l/well), approximately 55%-70% will adhere specifically. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain (Met 1-Thr 274) of human TROP2 (NP_002344.2) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus. |
| Purity: | > 98 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 55.7 kDa |
| AP Mol Mass: | 65-75 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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