Human TOP2B / DNA topoisomerase II beta ELISA Kit

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SKU:
HUFI01088
Product Type:
ELISA Kit
Size:
96 Assays
Uniprot:
Q02880
Sensitivity:
0.094ng/ml
Range:
0.156-10ng/ml
ELISA Type:
Sandwich
Synonyms:
TOP2B, DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme, TOPIIB, top2beta
Reactivity:
Human

Description

Human TOP2B / DNA topoisomerase II beta ELISA Kit

TOP2B is DNA topoisomerase, which regulates and changes the topology of DNA during transcription. Chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication are all processes that TOP2B is involved in. TOP2B catalyses the transient breaking and rejoining of two strands of duplex DNA, allowing the strands to pass through each other and altering DNA's topology. Several anticancer drugs target TOP2B, and a variety of mutations in TOP2B have been linked to the development of drug resistance. B-Cell Immunodeficiency, Distal Limb Anomalies, and Urogenital Malformations are diseases linked to TOP2B.

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