Immune Checkpoint Recombinant Proteins
Human TNFSF12 Recombinant Protein (hFc Tag) (HDPT0123)
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- SKU:
- HDPT0123
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immune Checkpoint
Description
Human TNFSF12 Recombinant Protein (hFc Tag)
| Description: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. |
| Product name: | Human TNFSF12 Recombinant Protein (hFc Tag) |
| Synonyms: | APO3L; DR3LG; TNLG4A; TWEAK |
| Type: | protein |
| Size: | 50 µg |
| Name: | TNFSF12 |
| Origin: | Human |
| Source: | HEK293 |
| Protein Type: | Recombinant |
| Application: | Contact Technical Support |
| Purity: | > 95% |
| Purification: | affinity purification |
| Format: | Lyophilized |
| Conjugate: | N-Human Fc tag |
| Storage: | Store at -80°C for 12 months (Avoid repeated freezing and thawing) |
| Usage: | Research use only |
| Buffer: | Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization. |
| Reconstitution: | Reconstitute with deionized water |
| Sequence: | hFc(Glu99-Ala330)+TNFSF12(Ser94-His249) |
| Gene ID: | 8742 |
| Uniprot: | O43508 |
| Molecular Weight: | 43.3 kDa |
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