Cytokines Recombinant Proteins

Human TNFRSF8 Recombinant Protein (RPPB1022)

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SKU:
RPPB1022
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P28908
Research Area:
Cytokines

Description

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Product Name:Human TNFRSF8 Recombinant Protein
Product Code:RPPB1022
Size:10µg
Species:Human
Target:TNFRSF8
Synonyms:Tumor Necrosis Factor Receptor Superfamily, Member 8,Lymphocyte Activation Antigen CD30, CD30L Receptor, Ki-1 Antigen, D1S166E,CD30, Cytokine Receptor CD30, CD30 Antigen, Ki-1.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:TNFRSF8protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPFPQDRPF EDTCHGNPSH YYDKAVRRCC YRCPMGLFPT QQCPQRPTDC RKQCEPDYYL DEADRCTACV TCSRDDLVEK TPCAWNSSRV CECRPGMFCS TSAVNSCARC FFHSVCPAGM IVKFPGTAQK NTVCEPASPG VSPACASPEN CKEPSSGTIP QAKPTPVSPA TSSASTMPVR GGTRLAQEAA SKLTRAPDSP SSVGRPSSDP GLSPTQPCPE GSGDCRKQCE PDYYLDEAGR CTACVSCSRD DLVEKTPCAW NSSRTCECRP GMICATSATN SCARCVPYPI CAAETVTKPQ DMAEKDTTFE APPLGTQPDC NPTPENGEAP ASTSPTQSLL VDSQASKTLP IPTSAPVALS STGKHHHHHH

Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) is a receptor for TNFSF8/CD30L. TNFRSF8 has a role in the regulation of cellular growth and transformation of activated lymphoblasts. In addition, the TNFRSF8 protein regulates gene expression via activation of NF-kappa-B. TNFRSF8 being a regulator of apoptosis, induces cell death or proliferation, depending on the cell type.

TNFRSF8 produced in Sf9 Baculovirus cells is a single,glycosylated polypeptide chain containing 370 amino acids (19-379 a.a.) andhaving a molecular mass of 39.5kDa (Migrates at 40-57kDa on SDS-PAGE underreducing conditions).TNFRSF8 is expressed with a 9 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function:transmembrane receptor activity

Biological Process: positive regulation of tumor necrosis factor biosynthetic process; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; signal transduction

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
UniProt Code:P28908
NCBI GenInfo Identifier:115978
NCBI Gene ID:943
NCBI Accession:P28908.1
UniProt Secondary Accession:P28908,Q6P4D9, B1AN79, B9EGD9, D3YTD8,
UniProt Related Accession:P28908
Molecular Weight:50,935 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 8
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 8
NCBI Official Symbol:TNFRSF8��
NCBI Official Synonym Symbols:CD30; Ki-1; D1S166E��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 8
UniProt Synonym Protein Names:CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen: CD30
UniProt Gene Name:TNFRSF8��
UniProt Entry Name:TNR8_HUMAN
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