Cytokines Recombinant Proteins

Human TNFRSF6B Recombinant Protein (RPPB1017)

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SKU:
RPPB1017
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95407
Research Area:
Cytokines

Description

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Product Name:Human TNFRSF6B Recombinant Protein
Product Code:RPPB1017
Size:20µg
Species:Human
Target:TNFRSF6B
Synonyms:Tumor Necrosis Factor Receptor Superfamily, Member 6b Decoy, Decoy Receptor For Fas Ligand, Decoy Receptor 3, DCR3, M68E, M68, TR6, DJ583P15.1.1, DcR3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:TNFRSF6B protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSVAETPTY PWRDAETGER LVCAQCPPGT FVQRPCRRDS PTTCGPCPPR HYTQFWNYLE RCRYCNVLCG EREEEARACH ATHNRACRCR TGFFAHAGFC LEHASCPPGA GVIAPGTPSQ NTQCQPCPPG TFSASSSSSE QCQPHRNCTA LGLALNVPGS SSHDTLCTSC TGFPLSTRVP GAEECERAVI DFVAFQDISI KRLQRLLQAL EAPEGWGPTP RAGRAALQLK LRRRLTELLG AQDGALLVRL LQALRVARMP GLERSVRERF LPVH

TNFRSF6B is a member of the Tumor necrosis factor receptor superfamily. TNFRSF6B performs as a decoy receptor which races against death receptors for ligand binding. TNFRSF6B has a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation in addition to inducing angiogenesis via neutralization of TL1A.

TNFRSF6B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 294 amino acids (30-300aa) and having a molecular mass of 32.1kDa.TNFRSF6B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TNFRSF6B: Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis. Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.3

Cellular Component: extracellular space

Molecular Function:protein binding; receptor activity

Biological Process: apoptosis; negative regulation of apoptosis

NCBI Summary:This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
UniProt Code:O95407
NCBI GenInfo Identifier:14790170
NCBI Gene ID:8771
NCBI Accession:NP_116563.1
UniProt Related Accession:O95407
Molecular Weight:32,680 Da
NCBI Full Name:
NCBI Synonym Full Names:TNF receptor superfamily member 6b
NCBI Official Symbol:TNFRSF6B��
NCBI Official Synonym Symbols:M68; TR6; DCR3; M68E; DJ583P15.1.1��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 6B
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 6B
UniProt Synonym Protein Names:Decoy receptor 3; DcR3; Decoy receptor for Fas ligand; M68
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:TNFRSF6B��
UniProt Entry Name:TNF6B_HUMAN
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