Cytokines Recombinant Proteins

Human TNFRSF25 Recombinant Protein (RPPB1042)

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RPPB1042

Description

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Product Name:Human TNFRSF25 Recombinant Protein
Product Code:RPPB1042
Size:10µg
Species:Human
Target:TNFRSF25
Synonyms:Tumor necrosis factor receptor superfamily member 25, TNFRSF25, TNF Ligand Receptor Superfamily Member 25, APO-3, DDR3, DR3, LARD, TNFRSF12, TR3, TRAMP, WSL-1, WSL-LR, Apo-3, Apoptosis-inducing receptor AIR, Protein WSL, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, Lymphocyte-associated receptor of death.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered clear solution.
Formulation:TNFRSF25 protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by analysis by SDS-PAGE.
Amino Acid Sequence:ADPQGGTRSP RCDCAGDFHK KIGLFCCRGC PAGHYLKAPC TEPCGNSTCL VCPQDTFLAW ENHHNSECAR CQACDEQASQ VALENCSAVA DTRCGCKPGW FVECQVSQCV SSSPFYCQPC LDCGALHRHT RLLCSRRDTD CGTCLPGFYE HGDGCVSCPT STLGSCPERC AAVCGWRQLE PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG KHHHHHH

TNFLigand Receptor Superfamily Member 25 (TNFRSF25) belongs to the TNF receptorsuperfamily that binds to the TNF-like protein TL1A. TNFRSF25 interactsdirectly with the adapter TRADD and regulates lymphocyte homeostasis. TNFRSF25is also mediates activation of NF-kappa-B and induces apoptosis. TNFRSF25signals are vital to exert T helper cell 2 effector activity in Th2-polarizedCD4 cells and co-stimulate interleukin-13 production byglycosphingolipid-activated NKT cells.

TNFRSF25 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 417 amino acids (25-199) and having a molecular mass of 46.1kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). TNFRSF25 is fused to a 242 amino acid IgG His-Tag at C-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
UniProt Code:Q93038
NCBI GenInfo Identifier:2501233
NCBI Gene ID:8718
NCBI Accession:Q93038.2
UniProt Secondary Accession:Q93038,O00275, O00276, O00277, O00278, O00279, O00280 O14865, O14866, B1ALX2, B1ALX3, B7ZLL7,
UniProt Related Accession:Q93038
Molecular Weight:29,111 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 25
NCBI Synonym Full Names:TNF receptor superfamily member 25
NCBI Official Symbol:TNFRSF25��
NCBI Official Synonym Symbols:DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 25
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 25
UniProt Synonym Protein Names:Apo-3; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; Death receptor 3; Lymphocyte-associated receptor of death; LARD; Protein WSL; Protein WSL-1
Protein Family:Tumor necrosis factor receptor superfamily
UniProt Gene Name:TNFRSF25��
UniProt Entry Name:TNR25_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q93038
Research Area:
Cytokines
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