Cell Death Recombinant Proteins
Human TNFRSF1B/CD120b Recombinant Protein (RPES1622)
- SKU:
- RPES1622
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Death
Description
Human TNFRSF1B/CD120b Recombinant Protein
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD; which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs; respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage; such as T and natural killer cells; as well as on endothelial cells; microglia; astrocytes;neurons; oligodendrocytes; cardiac myocytes; thymocytes; and mesenchymal stem cells.TNF RII binds to the membranebound forms of TNF? and Lymphotoxin?/TNFβ?soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.
| Product Name: | Human TNFRSF1B/CD120b Recombinant Protein (RPES1622) |
| Product Code: | RPES1622 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Tumor necrosis factor receptor superfamily member 1B, TNFRSF1B, Tumor necrosis factor receptor 2, TNF-R2, TNF-RII, Tumor necrosis factor receptor type II, p75, p80 TNF-alpha receptor, CD120b |
| Accession: | P20333 |
| Sequence: | Leu23-Asp257 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Tumor Necrosis Factor Receptor II is produced by our Mammalian expression system and the target gene encoding Leu23-Asp257 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 51.9 kDa |
| AP Mol Mass: | 60-90 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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