Cell Death Recombinant Proteins
Human TNFRSF19/TROY Recombinant Protein (RPES5174)
- SKU:
- RPES5174
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Death
Description
Human TNFRSF19/TROY Recombinant Protein
Tumor necrosis factor receptor superfamily; member 19 (TNFRSF19); also known as TAJ-alpha or TROY; is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the ductal epithelium of the prostate and parotid glands. TNFRSF19/TROY expression is detected in some adenocarcinoma cell lines that arise from this tissue. It has been shown to interact with TRAF family members; and to activate JNK signaling pathway when overexpressed in cells. TNFRSF19/TROY is capable of inducing apoptosis by a caspase-independent mechanism; and it is thought to play an essential role in embryonic development. TNFRSF19/TROY was negatively regulated by adipogenic transcription factor CCAAT/enhancer-binding proteins (C/EBP). TNFRSF19 signals activation of the Jnk pathway and induces cell death. Overexpression of TNFRSF19 also signals NFB activation; comparable and similar to that by p75NGFR. TNFRSF19/TROY is capable of activating key signaling pathways of the TNF receptor family; and its predominant expression patterns suggest that it plays a role in the growth and regulation of epithelial tissues.
| Product Name: | Human TNFRSF19/TROY Recombinant Protein (RPES5174) |
| Product Code: | RPES5174 |
| Size: | 100µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | TAJ,TAJ-alpha,TNFRSF19,TRADE,TROY |
| Accession: | Q9NS68-2 |
| Sequence: | Met 1-Leu170 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human TNFRSF19 (Q9NS68-2) (Met1-Leu170) was expressed with a polyhistidine tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 16.9 kDa |
| AP Mol Mass: | 28 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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