Cytokines Recombinant Proteins

Human TNFRSF17 Recombinant Protein (RPPB1040)

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SKU:
RPPB1040
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q02223
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human TNFRSF17 Recombinant Protein
Product Code:RPPB1040
Size:10µg
Species:Human
Target:TNFRSF17
Synonyms:BCMA, CD269, Tumor Necrosis Factor Receptor Superfamily Member 17, BCM, TNFRSF17, B-cell maturation protein, CD269 antigen
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:TNFRSF17 protein (0.5mg/ml) contains 10% glycerol and Phosphate-Buffered Saline (pH 7.4).
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPMLQMAGQ CSQNEYFDSL LHACIPCQLR CSSNTPPLTC QRYCNASVTN SVKGTNALEP KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW QQGNVFSCSV MHEALHNHYT QKSLSLSPGK HHHHHH

B-Cell Maturation Antigen or TNFRSF17 or tumor necrosis factor receptor superfamily member 17, is part of the TNF receptor protein family. This protein is a TNFSF13B/BLyS/BAFF, TNFSF13/APRIL & promotes B-cell survival receptor. TNFRSF17 has a crucial part in the humoral immunity regulation. This protein is responsible for the activation of NF-kappa-B & JNK.

TNFRSF17 Human Recombinant produced in Baculovirus is a single glycosylated polypeptide chain containing 296 amino acids (1-54 aa) and having a molecular mass of �33.1Da.TNFRSF17 is fused to a 242 amino acid hIgG-His-Tag at C-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.Protein type: Oncoprotein; Receptor, misc.; Membrane protein, integralChromosomal Location of Human Ortholog: 16p13.1Cellular Component: endomembrane system; integral to membrane; plasma membraneMolecular Function: receptor activityBiological Process: adaptive immune response; cell proliferation; lymphocyte homeostasis; multicellular organismal development; signal transduction; tumor necrosis factor-mediated signaling pathway
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
UniProt Code:Q02223
NCBI GenInfo Identifier:313104029
NCBI Gene ID:608
NCBI Accession:Q02223.2
UniProt Secondary Accession:Q02223,Q2TQ40
UniProt Related Accession:Q02223
Molecular Weight:14,843 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 17
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily member 17
NCBI Official Symbol:TNFRSF17��
NCBI Official Synonym Symbols:BCM; BCMA; CD269; TNFRSF13A��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 17
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 17
UniProt Synonym Protein Names:B-cell maturation protein; CD_antigen: CD269
Protein Family:
UniProt Gene Name:TNFRSF17��
UniProt Entry Name:TNR17_HUMAN
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