Cytokines Recombinant Proteins

Human TNFRSF17 Recombinant Protein (RPPB1039)

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SKU:
RPPB1039
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q02223
Research Area:
Cytokines

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human TNFRSF17 Recombinant Protein
Product Code:RPPB1039
Size:20µg
Species:Human
Target:TNFRSF17
Synonyms:BCMA, CD269, Tumor Necrosis Factor Receptor Superfamily Member 17, BCM, TNFRSF17, B-cell maturation protein, CD269 antigen.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless liquid.
Formulation:TNFRSF17 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSRKINSEP LKDEFKNTGS GLLGMANIDL EKSRTGDEII LPRGLEYTVE ECTCEDCIKS KPKVDSDHCF PLPAMEEGAT ILVTTKTNDY CKSLPAALSA TEIEKSISAR

TNFRSF17 is a receptor for tnfsf13b/blys/baff and tnfsf13/april. TNFRSF17 promotes b-cell survival and plays a role in the regulation of humoral immunity. TNFRSF17 activates nf-kappa-b and jnk. TNFRSF17 is a member of the TNF-receptor superfamily. TNFRSF17 is expressed in mature B lymphocytes, and is invloved in B cell development and autoimmune response. TNFRSF17 specifically binds to the tumor TNFSF13B/TALL-1/BAFF, which causes NF-kappaB and MAPK8/JNK activation. TNFRSF17 binds to a variety of TRAF family members, and therefore transduces signals for cell survival and proliferation. TNFRSF17 is a type III membrane protein having 1 extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs. TNFRSF17 appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells.

TNFRSF17 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (78-184 a.a) and having a molecular mass of 14.1kDa.TNFRSF17 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.Protein type: Oncoprotein; Receptor, misc.; Membrane protein, integralChromosomal Location of Human Ortholog: 16p13.1Cellular Component: endomembrane system; integral to membrane; plasma membraneMolecular Function: receptor activityBiological Process: adaptive immune response; cell proliferation; lymphocyte homeostasis; multicellular organismal development; signal transduction; tumor necrosis factor-mediated signaling pathway
UniProt Protein Details:
NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq, Jul 2008]
UniProt Code:Q02223
NCBI GenInfo Identifier:313104029
NCBI Gene ID:608
NCBI Accession:Q02223.2
UniProt Secondary Accession:Q02223,Q2TQ40
UniProt Related Accession:Q02223
Molecular Weight:14,843 Da
NCBI Full Name:Tumor necrosis factor receptor superfamily member 17
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily member 17
NCBI Official Symbol:TNFRSF17��
NCBI Official Synonym Symbols:BCM; BCMA; CD269; TNFRSF13A��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 17
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 17
UniProt Synonym Protein Names:B-cell maturation protein; CD_antigen: CD269
Protein Family:
UniProt Gene Name:TNFRSF17��
UniProt Entry Name:TNR17_HUMAN
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