Description
Product Name: | Human TNFRSF11A Polyclonal Antibody |
Product Code: | CAB22547 |
Reactivity: | Human, Mouse, Rat |
Applications: | Western blotting |
Host Species: | Rabbit |
Purification Method: | Affinity purification |
Isotype: | IgG |
Reactivity: | Human, Mouse, Rat |
Tested Applications: | WB, ELISA |
Key Applications: | Western blotting |
Recommended Dilution: | WB 1:100-1:500 |
Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
Positive Samples: | C2C12 |
Cellular Location: | cytosol, external side of plasma membrane, plasma membrane |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus.
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 30-212 of human TNFRSF11A. (NP_003830.1). |
Sequence: | IAPPC TSEKH YEHLG RCCNK CEPGK YMSSK CTTTS DSVCL PCGPD EYLDS WNEED KCLLH KVCDT GKALV AVVAG NSTTP RRCAC TAGYH WSQDC ECCRR NTECA PGLGA QHPLQ LNKDT VCKPC LAGYF SDAFS STDKC RPWTN CTFLG KRVEH HGTEK SDAVC SSSLP ARKPP NEPHV YLP |
Synonyms: | FEO, OFE, ODFR, OSTS, PDB2, RANK, CD265, OPTB7, TRANCER, LOH18CR1, TRANCE-R |
Calculated MW: | 66kDa |
Observed MW: | 100kDa |