Cytokines Recombinant Proteins

Human TNFRSF10C Recombinant Protein (RPPB1028)

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RPPB1028

Description

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Product Name:Human TNFRSF10C Recombinant Protein
Product Code:RPPB1028
Size:25µg
Species:Human
Target:TNFRSF10C
Synonyms:Tumor Necrosis Factor Receptor Superfamily, Member 10c,Decoy Without An , Intracellular Domain, TRAILR3, DCR1, TRID, TNF-RelatedApoptosis-Inducing Ligand Receptor, Antagonist Decoy Receptor For TRAIL/Apo-2L,Decoy TRAIL Receptor Without Death Domain, Lymphocyte Inhibitor Of TRAIL, DecoyReceptor,TRAIL-R, LIT,Tumor Necrosis Factor Receptor Superfamily Member 10C, TRAILReceptor Without an Intracellular Domain, Cytotoxic TRAIL Receptor, TRAILReceptor, CD263 Antigen, DCR1-TNFR, CD263.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:TNFRSF10C protein solution (1mg/ml) containing Phosphatebuffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHHSSGLVPRGSH MGSATTARQEEVPQQTVAPQ QQRHSFKGEE CPAGSHRSEH TGACNPCTEG VDYTNASNNE PSCFPCTVCK SDQKHKSSCTMTRDTVCQCK EGTFRNENSP EMCRKCSRCP SGEVQVSNCT SWDDIQCVEE FGANATVETP AAEETMNTSPGTPAPAAEET MNTSPGTPAP AAEETMTTSP GTPAPAAEET MTTSPGTPAP AAEETMTTSP GTPA

TRAIL Receptor-3, also known as TNFRSF10C belongs to the TNF-receptorsuper family. TNFRSF10C contains an extracellular TRAIL-binding domain as wellas a transmembrane domain, however no cytoplasmicdeath domain. Furthermore, TNFRSF10C is not capable of inducing apoptosis, andis considered to act as an antagonistic receptorwhich protects cells from TRAIL-induced apoptosis.

TNFRSF10C Human Recombinant produced in E. coli is asingle, non-glycosylated polypeptide chain containing 234 amino acids (26-236 a.a)and having a molecular mass of 24.6 kDa.TNFRSF10C is fused to a 23 amino acid His-tag atN-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TRAIL-R3: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand. Higher expression in normal tissues than in tumor cell lines. Highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung and heart.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 8p22-p21

Cellular Component: integral to plasma membrane

Molecular Function:transmembrane receptor activity; TRAIL binding

Biological Process: apoptosis; signal transduction

NCBI Summary:The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
UniProt Code:O14798
NCBI GenInfo Identifier:269849734
NCBI Gene ID:8794
NCBI Accession:O14798.3
UniProt Secondary Accession:O14798,O14755, Q08AS6, Q6FH98, Q6UXM5,
UniProt Related Accession:O14798
Molecular Weight:259
NCBI Full Name:Tumor necrosis factor receptor superfamily member 10C
NCBI Synonym Full Names:tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
NCBI Official Symbol:TNFRSF10C��
NCBI Official Synonym Symbols:LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR��
NCBI Protein Information:tumor necrosis factor receptor superfamily member 10C; decoy receptor 1; cytotoxic TRAIL receptor-3; lymphocyte inhibitor of TRAIL; decoy TRAIL receptor without death domain; antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligan
UniProt Protein Name:Tumor necrosis factor receptor superfamily member 10C
UniProt Synonym Protein Names:Antagonist decoy receptor for TRAIL/Apo-2L; Decoy TRAIL receptor without death domain; Decoy receptor 1; DcR1; Lymphocyte inhibitor of TRAIL; TNF-related apoptosis-inducing ligand receptor 3; TRAIL receptor 3; TRAIL-R3; TRAIL receptor without an intracellular domain; CD_antigen: CD263
Protein Family:Protein
UniProt Gene Name:TNFRSF10C��
UniProt Entry Name:TR10C_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O14798
Research Area:
Cytokines
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