Cytokines Recombinant Proteins
Human TNFAIP8 Recombinant Protein (RPPB1002)
- SKU:
- RPPB1002
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- O95379
- Research Area:
- Cytokines
Description
Product Name: | Human TNFAIP8 Recombinant Protein |
Product Code: | RPPB1002 |
Size: | 10µg |
Species: | Human |
Target: | TNFAIP8 |
Synonyms: | GG2-1; MDC-3.13, SCC-S2, SCCS2, Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, NF-kappa-B-inducible DED-containing protein, NDED, TNF-induced protein GG2-1, TNFAIP8. |
Source: | Escherichia Coli |
Physical Appearance: | Sterile filtered colorless solution. |
Formulation: | TNFAIP8 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT. |
Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
Purity: | Greater than 90% as determined by SDS-PAGE. |
Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMHSEAEE SKEVATDVFN SKNLAVQAQK KILGKMVSKS IATTLIDDTS SEVLDELYRV TREYTQNKKE AEKIIKNLIK TVIKLAILYR NNQFNQDELA LMEKFKKKVH QLAMTVVSFH QVDYTFDRNV LSRLLNECRE MLHQIIQRHL TAKSHGRVNN VFDHFSDCEF LAALYNPFGN FKPHLQKLCD GINKMLDEEN I |
TNFAIP8 which is a part of the TNFAIP8 family acts as a negative mediator of apoptosis and takes part in tumor progression. TNFAIP8 suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, resulting in inhibition of BID cleavage and activation of caspase-3.
TNFAIP8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (1-198a.a.) and having a molecular mass of 25kDa. TNFAIP8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
UniProt Protein Function: | TNFAIP8: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Belongs to the TNFAIP8 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q23.1 Cellular Component: cytoplasm Molecular Function:caspase inhibitor activity Biological Process: defense response to Gram-positive bacterium; interleukin-1 beta production; negative regulation of caspase activity; negative regulation of apoptosis |
UniProt Code: | O95379 |
NCBI GenInfo Identifier: | 74735587 |
NCBI Gene ID: | 25816 |
NCBI Accession: | O95379.1 |
UniProt Secondary Accession: | O95379,Q9P1Q1, Q9UER5, Q9UP47, B3KMH1, B3KMI2, B7Z713 |
UniProt Related Accession: | O95379 |
Molecular Weight: | 24,385 Da |
NCBI Full Name: | Tumor necrosis factor alpha-induced protein 8 |
NCBI Synonym Full Names: | tumor necrosis factor, alpha-induced protein 8 |
NCBI Official Symbol: | TNFAIP8�� |
NCBI Official Synonym Symbols: | NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13�� |
NCBI Protein Information: | tumor necrosis factor alpha-induced protein 8; TNF-induced protein GG2-1; TNF alpha-induced protein 8; NF-kappa-B-inducible DED-containing protein; head and neck tumor and metastasis-related protein |
UniProt Protein Name: | Tumor necrosis factor alpha-induced protein 8 |
UniProt Synonym Protein Names: | Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1 |
Protein Family: | Tumor necrosis factor alpha-induced protein |
UniProt Gene Name: | TNFAIP8�� |
UniProt Entry Name: | TFIP8_HUMAN |