Cytokines Recombinant Proteins

Human TNFAIP8 Recombinant Protein (RPPB1002)

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SKU:
RPPB1002
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95379
Research Area:
Cytokines

Description

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Product Name:Human TNFAIP8 Recombinant Protein
Product Code:RPPB1002
Size:10µg
Species:Human
Target:TNFAIP8
Synonyms:GG2-1; MDC-3.13, SCC-S2, SCCS2, Tumor necrosis factor alpha-induced protein 8, TNF alpha-induced protein 8, Head and neck tumor and metastasis-related protein, NF-kappa-B-inducible DED-containing protein, NDED, TNF-induced protein GG2-1, TNFAIP8.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:TNFAIP8 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMHSEAEE SKEVATDVFN SKNLAVQAQK KILGKMVSKS IATTLIDDTS SEVLDELYRV TREYTQNKKE AEKIIKNLIK TVIKLAILYR NNQFNQDELA LMEKFKKKVH QLAMTVVSFH QVDYTFDRNV LSRLLNECRE MLHQIIQRHL TAKSHGRVNN VFDHFSDCEF LAALYNPFGN FKPHLQKLCD GINKMLDEEN I

TNFAIP8 which is a part of the TNFAIP8 family acts as a negative mediator of apoptosis and takes part in tumor progression. TNFAIP8 suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, resulting in inhibition of BID cleavage and activation of caspase-3.

TNFAIP8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 221 amino acids (1-198a.a.) and having a molecular mass of 25kDa. TNFAIP8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TNFAIP8: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation. Belongs to the TNFAIP8 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 5q23.1

Cellular Component: cytoplasm

Molecular Function:caspase inhibitor activity

Biological Process: defense response to Gram-positive bacterium; interleukin-1 beta production; negative regulation of caspase activity; negative regulation of apoptosis

UniProt Code:O95379
NCBI GenInfo Identifier:74735587
NCBI Gene ID:25816
NCBI Accession:O95379.1
UniProt Secondary Accession:O95379,Q9P1Q1, Q9UER5, Q9UP47, B3KMH1, B3KMI2, B7Z713
UniProt Related Accession:O95379
Molecular Weight:24,385 Da
NCBI Full Name:Tumor necrosis factor alpha-induced protein 8
NCBI Synonym Full Names:tumor necrosis factor, alpha-induced protein 8
NCBI Official Symbol:TNFAIP8��
NCBI Official Synonym Symbols:NDED; GG2-1; SCCS2; SCC-S2; MDC-3.13��
NCBI Protein Information:tumor necrosis factor alpha-induced protein 8; TNF-induced protein GG2-1; TNF alpha-induced protein 8; NF-kappa-B-inducible DED-containing protein; head and neck tumor and metastasis-related protein
UniProt Protein Name:Tumor necrosis factor alpha-induced protein 8
UniProt Synonym Protein Names:Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1
Protein Family:Tumor necrosis factor alpha-induced protein
UniProt Gene Name:TNFAIP8��
UniProt Entry Name:TFIP8_HUMAN
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