Cell Cycle Recombinant Proteins
Human TLK1/PKU-beta Recombinant Protein (RPES0925)
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- SKU:
- RPES0925
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Cycle
Description
system_update_altDatasheet
Human TLK1/PKU-beta Recombinant Protein
The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene.
| Product Name: | Human TLK1/PKU-beta Recombinant Protein (RPES0925) |
| Product Code: | RPES0925 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | KIAA0137,PKU-beta |
| Accession: | Q9UKI8-1 |
| Sequence: | Met 1-Tyr 766 |
| Fusion tag: | N-His & GST |
| Activity: | The specific activity was determined to be 1.6 nmol/min/mg using Histone H3 protein as substrate. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human TLK1 isoform 1 (Q9UKI8-1) (Met 1-Tyr 766) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. |
| Purity: | > 88 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 114 kDa |
| AP Mol Mass: | 125 kDa |
| Formulation: | Supplied as sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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