Human TIMP2/TIMP-2 Recombinant Protein (RPES4350)

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SKU:
RPES4350
Product Type:
Recombinant Protein
Species:
Human

Description

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Human TIMP2/TIMP-2 Recombinant Protein

Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family consists of four members (TIMP1-4), and they bind to and inactivate most MMPs through non-covalent binary complexes. TIMP2 is a 22-kDa non-N-glycosylated protein present in a variety of cell types and with a distinct function among the TIMP family due to its functions in controlling cellular responses to growth factors. Findings establish an unexpected, MMP-independent mechanism for TIMP2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo. TIMP-2 is required for tissue homeostasis and is involved in the regulation of tumor microenvironment. Human TIMP2/TIMP-2 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

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