Immunology Recombinant Proteins

Human TIM-3/HAVCR2 Recombinant Protein (RPES4563)

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SKU:
RPES4563
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immunology

Description

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Human TIM-3/HAVCR2 Recombinant Protein

T-Cell Membrane Protein 3 (TIM3) is a single-pass type I membrane protein that belongs to the TIM family of immunoglobulin superfamily. TIM3 includes a signal sequence (aa 1-21); an extracellular region (aa 22-202) with one Ig-like V-type domain; a transmembrane segment (aa 203-223); and a cytoplasmic domain (aa 224 - 301). TIM3 regulates macrophage activation; inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and as a receptor for LGALS9.

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