Human TIFA Recombinant Protein (RPPB4960)
- SKU:
- RPPB4960
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q96CG3
Description
| Product Name: | Human TIFA Recombinant Protein |
| Product Code: | RPPB4960 |
| Size: | 10µg |
| Species: | Human |
| Target: | TIFA |
| Synonyms: | TRAF-interacting protein with FHA domain-containing protein A, Putative MAPK-activating protein PM14, Putative NF-kappa-B-activating protein 20, TRAF2-binding protein, TIFA, T2BP, T6BP, TIFAA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | TIFA protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMTSFED ADTEETVTCL QMTVYHPGQL QCGIFQSISF NREKLPSSEV VKFGRNSNIC HYTFQDKQVS RVQFSLQLFK KFNSSVLSFE IKNMSKKTNL IVDSRELGYL NKMDLPYRCM VRFGEYQFLM EKEDGESLEF FETQFILSPR SLLQENNWPP HRPIPEYGTY SLCSSQSSSP TEMDENES |
TRAF-interacting protein with FHA domain-containing protein A (TIFA) is an adapter protein that mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, triggering the downstream activation of NF-kappa-B and AP-1 pathways. The TIFA protein stimulates the oligomerization and polyubiquitination of TRAF6, leading to the activation of TAK1 and IKK through a proteasome-independent mechanism.
TIFA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 208 amino acids (1-184 a.a.) and having a molecular mass of 24kDa.TIFA is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | TIFA: Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.Chromosomal Location of Human Ortholog: 4q25Molecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96CG3 |
| NCBI GenInfo Identifier: | 74751795 |
| NCBI Gene ID: | 92610 |
| NCBI Accession: | Q96CG3.1 |
| UniProt Secondary Accession: | Q96CG3 |
| UniProt Related Accession: | Q96CG3 |
| Molecular Weight: | 21,445 Da |
| NCBI Full Name: | TRAF-interacting protein with FHA domain-containing protein A |
| NCBI Synonym Full Names: | TRAF interacting protein with forkhead associated domain |
| NCBI Official Symbol: | TIFA�� |
| NCBI Official Synonym Symbols: | T2BP; T6BP; TIFAA�� |
| NCBI Protein Information: | TRAF-interacting protein with FHA domain-containing protein A |
| UniProt Protein Name: | TRAF-interacting protein with FHA domain-containing protein A |
| UniProt Synonym Protein Names: | Putative MAPK-activating protein PM14; Putative NF-kappa-B-activating protein 20; TRAF2-binding protein |
| Protein Family: | TRAF-interacting protein with FHA domain-containing protein |
| UniProt Gene Name: | TIFA�� |
| UniProt Entry Name: | TIFA_HUMAN |
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