Cardiovascular Recombinant Proteins

Human Tie1 Recombinant Protein (RPES1783)

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SKU:
RPES1783
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cardiovascular

Description

system_update_altDatasheet

Human Tie1 Recombinant Protein

TIE-1 (Tyrosine Kinase with Ig and EGF Homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily. These receptors are expressed on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis. Human TIE-1 cDNA encodes a 1124 amino acid (aa) residue precursor protein with an 18aa signal peptide, a 727 aa extracellular domain and a 354 aa cytoplasmic domain. so far, two ligands have been described for TIE-2 [angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2)], but no ligand was found for TIE-1.

Product Name:Human Tie1 Recombinant Protein (RPES1783)
Product Code:RPES1783
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Tyrosine-Protein Kinase Receptor Tie-1, TIE1, TIE
Accession:P35590
Sequence:Ala22-Gln760
Fusion tag:C-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains 1 is produced by our Mammalian expression system and the target gene encoding Ala22-Gln760 is expressed with a 6His tag at the C-terminus.
Purity:> 90 % as determined by reducing SDS-PAGE.
Mol Mass:81.0 kDa
AP Mol Mass:87 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM MES, 150mM NaCl, pH 5.5.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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system_update_altDatasheetHuman Tie1 Recombinant Protein Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as Tie1 is an angiopoietin receptor and is an orphan receptor t