Human TIAL1 Recombinant Protein (RPPB4958)

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RPPB4958

Description

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Product Name:Human TIAL1 Recombinant Protein
Product Code:RPPB4958
Size:20µg
Species:Human
Target:TIAL1
Synonyms:TCBP, TIAR, TIA1 cytotoxic granule-associated RNA bindingprotein-like 1, TIA-1-related protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:TIAL1 protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 50% glycerol, 2mM DTT and 1mM EDTA .
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMMEDDGQ PRTLYVGNLS RDVTEVLILQ LFSQIGPCKS CKMITEHTSNDPYCFVEFYE HRDAAAALAA MNGRKILGKE VKVNWATTPS SQKKDTSNHF HVFVGDLSPE ITTEDIKSAFAPFGKISDAR VVKDMATGKS KGYGFVSFYN KLDAENAIVH MGGQWLGGRQ IRTNWATRKP PAPKSTQENNTKQLRFEDVV NQSSPKNCTV YCGGIASGLT DQLMRQTFSP FGQIMEIRVF PEKGYSFVRF STHESAAHAIVSVNGTTIEG HVVKCYWGKE SPDMTKNFQQ VDYSQWGQWS QVYGNPQQYG QYMANGWQVP PYGVYGQPWNQQGFGVDQSP SAAWMGGFGA QPPQGQAPPP VIPPPNQAGY GMASYQTQ

TIAL1 belongs to a family of RNA-binding proteins, it has 3 RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a extensive range of genes. TIAL1 regulates a variety of activities including translational control, splicing and apoptosis. TIAL1 different isoforms function differently with respect to post-transcriptional silencing.

TIAL1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 398 amino acids (1-375 a.a) andhaving a molecular mass of 44.0kDa.TIAL1 is fusedto a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TIAL1: a member of a family of RNA-binding proteins that possesses nucleolytic activity. A cytotoxic T cell granule-associated protein that has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. Members of this protein family may be involved in the induction of apoptosis. Two splice variant isoforms have been described.
UniProt Protein Details:

Protein type:RNA-binding; Apoptosis

Chromosomal Location of Human Ortholog: 10q

Cellular Component: stress granule; lysosome; cytoplasm; nucleus

Molecular Function:RNA binding; nucleotide binding; AU-rich element binding

Biological Process: regulation of transcription from RNA polymerase II promoter; apoptosis; stem cell division; positive regulation of cell proliferation; defense response; germ cell development

NCBI Summary:The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
UniProt Code:Q01085
NCBI GenInfo Identifier:267131
NCBI Gene ID:7073
NCBI Accession:Q01085.1
UniProt Secondary Accession:Q01085,P70318,
UniProt Related Accession:Q01085
Molecular Weight:375
NCBI Full Name:Nucleolysin TIAR
NCBI Synonym Full Names:TIA1 cytotoxic granule-associated RNA binding protein-like 1
NCBI Official Symbol:TIAL1��
NCBI Official Synonym Symbols:TCBP; TIAR��
NCBI Protein Information:nucleolysin TIAR; T-cluster binding protein; TIA-1-related nucleolysin; aging-associated gene 7 protein
UniProt Protein Name:Nucleolysin TIAR
UniProt Synonym Protein Names:TIA-1-related protein
UniProt Gene Name:TIAL1��
UniProt Entry Name:TIAR_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q01085
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