Human TIAF1 Recombinant Protein (RPPB4957)

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RPPB4957

Description

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Product Name:Human TIAF1 Recombinant Protein
Product Code:RPPB4957
Size:10µg
Species:Human
Target:TIAF1
Synonyms:TGFB1-Induced Anti-Apoptotic Factor 1, 12 KDa TGF-Beta-1-Induced Antiapoptotic Factor, Molecule Associated With Jak-3 N-Terminal, KIAA0216, MYO18A, MYSPDZ, MAJN, SPR210.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The TIAF1 solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSS PSSPFREQSF LCAAGDAGEE SRVQVLKNEV RRGSPVLLGW VEQAYADKCV CGPSAPPAPT PPSLSQRVMC NDLFKVNPFQ LQQFRADPST ASLLLCPGGL DHKLNLRGKA WG

TGFB1-induced anti-apoptotic factor 1 (TIAF1) hinders the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. The TIAF1 protein is involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation. TIAF1 is not detected in normal kidney and liver. TIAF1 is up-regulated in chronic and acute allograft rejection: expressed in the inflammatory infiltrate and in tubular epithelial cells.

TIAF1 Human Recombinant produced in E. coli is a single polypeptide chain containing 152 amino acids (1-115) and having a molecular mass of 16.6 kDa.TIAF1 is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:TIAF1: Inhibits the cytotoxic effects of TNF-alpha and overexpressed TNF receptor adapters TRADD, FADD, and RIPK1. Involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: nucleus

Biological Process: I-kappaB kinase/NF-kappaB cascade; apoptosis; negative regulation of apoptosis

UniProt Code:O95411
NCBI GenInfo Identifier:17978509
NCBI Gene ID:9220
NCBI Accession:NP_004731
UniProt Secondary Accession:O95411,Q6PEG2, A2RRE2,
UniProt Related Accession:O95411
Molecular Weight:12,414 Da
NCBI Full Name:TGFB1-induced anti-apoptotic factor 1
NCBI Synonym Full Names:TGFB1-induced anti-apoptotic factor 1
NCBI Official Symbol:TIAF1��
NCBI Official Synonym Symbols:MAJN; SPR210��
NCBI Protein Information:TGFB1-induced anti-apoptotic factor 1; TGF-beta-1-induced antiapoptotic factor 1; molecule associated with Jak-3 N-terminal; 12 kDa TGF-beta-1-induced antiapoptotic factor
UniProt Protein Name:TGFB1-induced anti-apoptotic factor 1
UniProt Synonym Protein Names:12 kDa TGF-beta-1-induced antiapoptotic factor
UniProt Gene Name:TIAF1��
UniProt Entry Name:TIAF1_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95411
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