Natural Proteins Recombinant Proteins

Human Thyroglobulin Recombinant Protein (RPPB5151)

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SKU:
RPPB5151
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P01266
Research Area:
Natural Proteins

Description

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Product Name:Human Thyroglobulin Recombinant Protein
Product Code:RPPB5151
Size:100µg
Species:Human
Target:Thyroglobulin
Synonyms:Thyroglobulin, TGN, AITD3, TG.
Source:Native, Isolated from human thyroid glands
Physical Appearance:Sterile Filtered solution.
Formulation:Human Thyroglobulin biotinylated is supplied at a 20mM HEPES buffer pH-7.6, 150mM NaCl and 40% Sucrose (w/v).
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�Avoid multiple freeze-thaw cycles.
Purity:Greater than 80% as determined by SDS-PAGE.

Thyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen.Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease.

Human Thyroglobulin is a biotinylated, glycosylated, polypeptide chain having a total molecular mass of 662 kDa (331 kDa per subunit).

UniProt Protein Function:Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
NCBI Summary:Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
UniProt Code:P01266
NCBI GenInfo Identifier:126302607
NCBI Gene ID:7038
NCBI Accession:P01266.5
UniProt Secondary Accession:P01266,O15274, O43899, Q15593, Q15948, Q9NYR1, Q9NYR2 Q9UMZ0, Q9UNY3,
UniProt Related Accession:P01266
Molecular Weight:298,383 Da
NCBI Full Name:Thyroglobulin
NCBI Synonym Full Names:thyroglobulin
NCBI Official Symbol:TG��
NCBI Official Synonym Symbols:TGN; AITD3��
NCBI Protein Information:thyroglobulin
UniProt Protein Name:Thyroglobulin
Protein Family:Thyroglobulin
UniProt Gene Name:TG��
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