Human THRSP Recombinant Protein (RPPB4955)

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RPPB4955

Description

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Product Name:Human THRSP Recombinant Protein
Product Code:RPPB4955
Size:20µg
Species:Human
Target:THRSP
Synonyms:Lpgp, LPGP1, S14, SPOT14, THRP, Spot 14 protein.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:THRSP protein solution (1mg/ml) contains 20mM Tris-HCl buffer, (pH 8.0), 0.15M NaCl and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMQVLTKR YPKNCLLTVM DRYAAEVHNM EQVVMIPSLL RDVQLSGPGG QAQAEAPDLY TYFTMLKAIC VDVDHGLLPR EEWQAKVAGS EENGTAETEE VEDESASGEL DLEAQFHLHF SSLHHILMHL TEKAQEVTRK YQEMTGQVW

Thyroid Hormone Responsive (THRSP) is a member of the SPOT14 family. THRSP is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. THRSP is expressed in liver and adipocytes, specifically in lipomatous modules. In addition It is expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism.

THRSP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 169 amino acids (1-146 a.a.) and having a molecular mass of 18.9kDa.THRSP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:THRSP: Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB. Belongs to the SPOT14 family.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 11q14.1

Cellular Component: nucleoplasm; cytosol

Molecular Function:protein homodimerization activity

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; lipid metabolic process; regulation of lipid biosynthetic process

NCBI Summary:The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]
UniProt Code:Q92748
NCBI GenInfo Identifier:2842710
NCBI Gene ID:7069
NCBI Accession:Q92748.1
UniProt Secondary Accession:Q92748,B2R4W7,
UniProt Related Accession:Q92748
Molecular Weight:146
NCBI Full Name:Thyroid hormone-inducible hepatic protein
NCBI Synonym Full Names:thyroid hormone responsive
NCBI Official Symbol:THRSP��
NCBI Official Synonym Symbols:S14; Lpgp; THRP; LPGP1; SPOT14��
NCBI Protein Information:thyroid hormone-inducible hepatic protein; SPOT14 homolog; spot 14 protein; lipogenic protein 1; thyroid hormone responsive SPOT14; thyroid hormone responsive (SPOT14 homolog, rat)
UniProt Protein Name:Thyroid hormone-inducible hepatic protein
UniProt Synonym Protein Names:Spot 14 protein; S14; SPOT14
Protein Family:Thyroid hormone-inducible hepatic protein
UniProt Gene Name:THRSP��
UniProt Entry Name:THRSP_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q92748
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